A Phase I Trial of QLS2313 Injection in Relapsed/Refractory Hematological Malignancies

Inclusion Criteria: 1. Males or females aged ≥ 18 years； 2. Patients with relapsed/refractory hematological malignancies, specifically patients with B-cell NHL or CLL/small lymphocytic lymphoma (SLL) as defined by the 2022 World Health Organization (WHO) classification, who are relapsed/refractory and have no standard of care available as judged by the investigator; 3. Having a measurable disease defined by appropriate disease response criteria; 4. Subjects with sufficient organ function prior to the first dose of the investigational drug 5. Eastern Cooperative Oncology Group (ECOG) performance status (PS) score: 0 or 1 Exclusion Criteria: 1. Previous treatment with a CD79b/CD3/CD20 trispecific antibody； 2. Known central nervous system (CNS) involvement； 3. Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation/bone marrow transplantation； 4. Treatment with autologous stem cell transplantation within 3 months; 5. Prior genetically modified adoptive cell therapy (e.g., chimeric antigen receptor T cells \[CAR-T\] and natural killer cells \[CAR-NK\]) within 3 months 6. Presence of viral, bacterial or uncontrolled fungal infection requiring intravenous drug infusion within 1 week prior to the first dose 7. Presence of chronic or acute active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, defined as HBV-5 test at screening indicating active infection (positive HBsAg and/or positive HBcAb) with HBV-DNA \> ULN, or positive HCVAb and positive HCV-RNA, allowed for antiviral therapy.