Al18F-NOTA-LM3 PET/CT in Patients With Pheochromocytoma and Paraganglioma

NCT07288931 · tracked via the Priya Life Science China tracker

Sponsor

Peking Union Medical College Hospital

Phase

Not applicable

Started

2024-08-06

Last updated

2025-12-17

Condition(s) studied

Pheochromocytoma/Paraganglioma (PPGL)

Investigational drug(s) / intervention(s)

Diagnostic Test: Al18F-NOTA-LM3Diagnostic Test: 68Ga-DOTATATE

Diagnostic Test: Al18F-NOTA-LM3: Patients will receive a single intravenous injection of Al18F-NOTA-LM3. Subsequently, a PET/CT scan will be performed within 60 to 120 minutes post-injection.

Diagnostic Test: 68Ga-DOTATATE: Patients will receive a single intravenous injection of 68Ga-DOTATATE. Subsequently, a PET/CT scan will be performed within 40 to 60 minutes post-injection.

Study summary

The aim of this study is to evaluate the diagnostic performance of Al18F-NOTA-LM3 PET/CT and compare it with 68Ga-DOTATATE PET/CT in patients with pheochromocytoma/paraganglioma (PPGL).

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria: * Patients aged 18 to 80 years. * Suspected or confirmed PPGL patients. Exclusion Criteria: * Combined with other types of tumors. * Severe liver or renal dysfunction (ALT/AST≥5 ULN, GFR\<30ml/min). * Pregnant or breast-feeding women. * Inability to perform PET/CT scans.

Primary outcome measure(s)

Tumor Detection Rate — From study completion to 6 months after completion.
Compare the number of tumor detected by Al18F-NOTA-LM3 PET/CT and 68Ga-DOTATATE PET/CT

Trial sites (1)

Facility	City	Region	Status
Peking Union Medical College Hospital	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07288931 on ClinicalTrials.gov ↗ ← All trials in China