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Clinical Trials in China / NCT07275840
Recruiting Phase 2

A Study to Evaluate the Efficacy and Safety of IBI302inSubjects With nAMD

NCT07275840 · tracked via the Priya Life Science China tracker
Sponsor
Innovent Biologics Technology Limited (Shanghai R&D Center)
Phase
Phase 2
Started
2025-12-05
Last updated
2026-01-08

Condition(s) studied

Neovascular Age-related Macular Degeneration

Investigational drug(s) / intervention(s)

IBI302 8mg dose

IBI302 8mg dose: 8 mg IBI302 will be administered by intravitreal injection into the study eye once every 4 weeks for 3 consecutive months, followed by once every 8 weeks.

Study summary

This study is designed for Open-label, multi-center, single-arm Phase II trail to evaluate the efficacy and safety of intravitreal injection of IBI302 in nAMD patients.

Eligibility

Sex
ALL
Min age
50 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Have signed an informed consent form before participating in the research. 2. Male or female individuals aged 50 or above at the time of signing the informed consent form; 3. Active CNV under the macular fovea secondary to nAMD or active CNV involving the macular fovea. 4. At baseline, the BCVA of the study eye was within the range of 19 to 78 ETDRS letters (including both ends). Exclusion Criteria: 1. According to the investigator's judgment, concomitant ocular diseases/systemic diseases of the study eyes at screening or baseline may lead to participants' non-response to the study treatment or confuse the interpretation of the study results; 2. The study eye has uncontrollable glaucoma; 3. There is an active intraocular or periocular infection or inflammation in either eye; 4. The non-study eye has severe visual function disorders; 5. Within 90 days before baseline, the study eye had received anti-VEGF treatment; 6. Within 90 days before baseline, the study eye had received anti-complement treatment; 7. At any time before baseline, the study eye had received IBI302 treatment; 8. Uncontrollable hypertension; 9. Glycated hemoglobin (HbA1c) \> 10.0% within 28 days prior to screening; 10. Other exclusion criteria set by protocol.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Shanghai general hospital Shanghai Shanghai Municipality Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07275840 on ClinicalTrials.gov ↗ ← All trials in China