Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke

Inclusion Criteria: 1. Age 18 years or greater, male or female; 2. Acute ischemic stroke onset within 14 days; 3. modified Rankin scale (mRS) score ≤ 3; 4. Signed informed consent from the patients or the legally authorized representatives. Exclusion Criteria: 1. Stroke progression within the past 3 days (defined as an increase in NIHSS score of ≥4 points or an increase in any single item of ≥2 points); 2. Concurrent osteoarthritis, fractures, deep vein thrombosis, unstable angina, severe heart diseases, respiratory diseases, or amputation that may theoretically make it difficult for participants to complete the physical exercise or ambulation; 3. Concurrent movement disorders such as Parkinson's disease or Parkinsonism; 4. Patients who have engaged in regular aerobic physical activity within the past 6 months, defined as more than 150 minutes of moderate-intensity aerobic physical activity; or more than 75 minutes of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous-intensity activity throughout the week; 5. Unable to comply with the study procedures or follow-up due to psychiatric, cognitive, or emotional disorders; 6. Known pregnancy or lactation, or a positive pregnancy test; 7. Currently participating in another drug or device study; 8. Life expectancy less than 1 year; 9. Unable to communicate using a smartphone; 10. Other conditions considered by investigators to be unsuitable for inclusion.