Whole Body MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Radiographic axSpA and Non-radiographic axSpA

Condition(s) studied

Investigational drug(s) / intervention(s)

Whole body MRI: These studies will be performed on a 3Tesla (T) MR system (Achieva, Philips Medical Systems) for all patients.

Study summary

This study aims to further improve and expand the WB-MRI imaging evaluation cohort of axSpA patients to complete dynamic follow-up and condition assessment. Based on the WB-MRI features, the association of WB-MRI signs with disease activity, inflammation, and structural damage will be analyzed. At the same time, in-depth data mining was conducted and machine learning was used to construct a new axSpA disease activity assessment model based on WB-MRI data, and the accuracy and reliability of the model were clearly evaluated in the discovery cohort and validation cohort.

Eligibility

Primary outcome measure(s)

• WB-MRI imaging characteristics of patients with axSpA. — Two years
  Compare the correlation between WB-MRI changes and disease activity, disease progression and structural damage at baseline and after 2 years of follow-up.

Trial sites (1)

More The First Affiliated Hospital with Nanjing Medical University trials in China

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