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Clinical Trials in China / NCT07229729
Recruiting Phase 2

A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer

NCT07229729 · tracked via the Priya Life Science China tracker
Sponsor
Shanghai Hengrui Pharmaceutical Co., Ltd.
Phase
Phase 2
Started
2025-11-24
Last updated
2025-12-01

Condition(s) studied

Non-small Cell Lung Cancer

Investigational drug(s) / intervention(s)

SHR-A2102AdebrelimabPaclitaxelCarboplatinAlomnertinib MesilateFurmonertini MesilateOsimertinib Mesylate

SHR-A2102: SHR-A2102.

Adebrelimab: Adebrelimab.

Paclitaxel: Paclitaxel.

Carboplatin: Carboplatin.

Alomnertinib Mesilate: Alomnertinib Mesilate.

Furmonertini Mesilate: Furmonertini Mesilate.

Osimertinib Mesylate: Osimertinib Mesylate.

Study summary

The study is a Phase II study to explore the efficacy and safety of SHR-A2102 in combination with other anti-tumor therapies as perioperative treatment in patients with resectable non-small cell lung cancer.

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria: 1. Voluntarily participate in this clinical study, understand the research procedures and be able to sign the informed consent form in writing; 2. Participants must be aged between 18 and 70 years old (inclusive) when signing the informed consent form, and both men and women are eligible; 3. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1; 4. Adequate organ function; 5. Women of childbearing age must undergo serum pregnancy tests, and the results must be negative. Female subjects of childbearing age and male subjects who are partners of women of childbearing age must agree to use highly effective contraceptive methods. Exclusion Criteria: 1. With active, known or suspected autoimmune disease of autoimmune disease; 2. Malignancies other than NSCLC within 5 years prior to randomization; 3. Has or suspected has a history of pneumonitis / interstitial lung disease or any serve lung diseases which will influence the examination of lung function; 4. Significant history of cardiovascular and cerebrovascular disease; Significant haemorrhagic disease; 5. Has an arteriovenous thrombotic events; 6. Has a known history of human immunodeficiency virus (HIV) infection; 7. Has a known active Hepatitis B or Hepatitis C; 8. Allergic to the intervention regimens.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Guangdong Provincial People's Hospital Guangzhou Guangdong Recruiting

More Shanghai Hengrui Pharmaceutical Co., Ltd. trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07229729 on ClinicalTrials.gov ↗ ← All trials in China