Intent of Surgery for IPMN

NCT07216521 · tracked via the Priya Life Science China tracker

Sponsor

NYU Langone Health

Phase

Observational

Started

2025-09-15

Last updated

2025-10-14

Condition(s) studied

Intraductal Papillary Mucinous Neoplasm

Study summary

This multicenter retrospective observational cohort study seeks to:

1. Classify surgical intent in patients with resected Intraductal Papillary Mucinous Neoplasms (IPMN) and quantify the proportion of IPMN-associated cancers diagnosed as overt pancreatic cancer with incidental IPMN association on pathology.
2. Compare clinicopathologic features and outcomes between surveillance-detected and incidentally detected IPMN-derived pancreatic cancers.
3. Revise and redefine risk features limited to patients undergoing surgery for IPMN-related indications, identifying optimal predictors of malignant IPMN (high-grade dysplasia or invasive cancer).

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * All patients (18 years old of greater) who underwent surgical resection for IPMN (including low-, high-grade dysplasia, or invasive carcinoma) between July 1, 2015 and July 1, 2025. Exclusion Criteria: * Patients with concomitant pancreatic ductal adenocarcinoma (PDAC)

Primary outcome measure(s)

Grade of IPMN on Final Pathology — Day 0 (Retrospective Analysis)

Trial sites (14)

Facility	City	Region	Status
Mayo Clinic	Phoenix	Arizona	Recruiting
Johns Hopkins University	Baltimore	Maryland	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	Recruiting
Mayo Clinic	Rochester	Minnesota	Recruiting
NYU Langone Health	New York	New York	Recruiting
Memorial Sloan Kettering	New York	New York	Recruiting
Duke University	Durham	North Carolina	Recruiting
MD Anderson Cancer Center	Houston	Texas	Recruiting
Nanjing University	Nanjing	China	Recruiting
Heidelberg University	Heidelberg	Germany	Recruiting
San Raffaele Hospital	Milan	Italy	Recruiting
Padua University	Padua	Italy	Recruiting
University of Amsterdam	Amsterdam	Netherlands	Recruiting
University of Utrecht	Utrecht	Netherlands	Recruiting

Other trials for the same condition

AI-powered Early Detection for Pancreatic Cancer Via Non-contrast CT in Opportunistic Screening Cohort Recruiting

Intra-operative Pancreatoscopy in Patients With IPMN Active, not recruiting

Exploring Biomarkers of the Carcinogenesis of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas Recruiting

Artificial Intelligence-powered Low-Dose Computed Tomography for Screening of Pancreatic Cancer Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07216521 on ClinicalTrials.gov ↗ ← All trials in China