SIBP-A10: SIBP-A10 injection. Strength: 0.5, 1.5, 3, 5, 7, 10 and 15 mg/kg. Intravenous infusion administration, with a treatment cycle of every 21 days, administered once on the first day of each cycle. The dose escalation stage,0.5 mg/kg group was subjected to accelerated titration, where the safety was evaluated within 21 days after the first administration to one subject. If unacceptable toxic reactions occurred, the traditional "3+3" dose escalation method was immediately switched. If unacceptable toxic reactions do not occur, the next dose group will be explored. The third stage will use RP2D for further exploration.
Study summary
To evaluate the safety, tolerability of SIBP-A10 and determine the maximum tolerable dose (MTD) and phase II recommended dose (RP2D).
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Voluntarily participate in this study and sign an informed consent form;
* Age range of 18 to 75 years old (including boundary values), gender not limited;
* The clinical diagnosis of enrolled subjects should meet the conditions specified in the protocol:
* There must be at least one measurable lesion as the target lesion;
* Backfilling queue during dose escalation stage, dose expansion stage, and indication expansion stage: able to provide tumor tissue samples that meet the requirements of the protocol or undergo tumor biopsy during screening, or provide testing reports issued by legitimate testing institutions that meet the requirements;
* I have not received any medication targeting Siglec-15 in the past;
* The Eastern Cooperative Oncology Group (ECOG) physical fitness score ranges from 0 to 1;
* Expected survival period ≥ 3 months;
* During the screening period, the main organ functions were basically normal;
* During the screening period, women of childbearing age had negative blood pregnancy tests, and reproductive age subjects (including male subjects) had no pregnancy plans during the trial period and within 6 months after the last dose, and voluntarily took effective contraceptive measures.
Exclusion Criteria:
* The subject has the following tumors:
* The subject has had other malignant tumors that have not healed within the past 5 years;
* Subjects with meningeal metastases;
* Subjects with active brain metastases;
* For anti-tumor subjects with a history of past treatment or surgery that does not comply with the protocol, or who have received treatment that does not comply with the protocol during the planned trial period
* Previous medical history or laboratory non-compliance with protocol requirements
* According to the researchers' assessment, the screening period is accompanied by severe, progressive, or uncontrolled non-tumor diseases, and it has been determined by the researchers that participating in the study would increase the risk for the subjects.
* According to the investigator's judgment, there are concomitant diseases (including but not limited to hypertension, diabetes, active infection, etc. that cannot be controlled by drugs) that seriously endanger the patient's safety or affect the patient's completion of the study
* Researchers determine that there are uncontrollable ascites, pleural effusion, or pericardial effusion, or those who have undergone ≥ 2 serosal drainage within 2 weeks prior to the first administration;
* Before starting treatment, the patient has not yet recovered to ≤ grade 1 from the toxic effects of previous treatments (including previous immunotherapy) and/or complications of previous surgical interventions.
* Individuals with a history of severe allergies to protein products, CHO cell products, other recombinant human or humanized antibodies, or components of the investigational drug;
* Pregnant and lactating women;
* Researchers believe that subjects who are not suitable to participate in this clinical study due to other reasons.
Primary outcome measure(s)
AE (Adverse Events) — From day 1 after the first dose to day 28 after the last dose That is adverse events, any adverse events that occurred to the subject during the study period.
Phase II recommended dose (RP2D) — Day 21 after the last dose in the dose expansion phase RP2D refers to the recommended dose determined through initial dose escalation and toxicity assessment in clinical trials, used for further evaluation of drug efficacy and safety.
Dose-limiting toxicity (DLT) — Day 21 after each dose in the dose escalation stage DLT is defined as any adverse event related to the drug defined in the protocol that occurs within 21 days of the first cycle after a single administration.
Maximum tolerated dose (MTD) — Day 21 after the last dose in the dose escalation stage MTD is defined as the maximum dose at which the number of DLT cases occurring during the DLT observation period within 21 days after a single administration is ≤ 1/6 of the total number of cases.
Trial sites (1)
Facility
City
Region
Status
Zhongshan Hospital Affiliated to Dalian University
Dalian
Liaoning
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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