Obtain the performance parameters and clinical consistency of mNGS and tNGS technologies in the pathogen diagnosis of lower respiratory tract specimens from patients with severe pulmonary infections, to provide a reference basis for the application value and true performance of these technologies in the pathogen diagnosis of patients with severe pulmonary infections.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Voluntary signing of the informed consent form.
2. Common respiratory infections: traditional methods cannot clearly identify and the patient's condition is prolonged without improvement; Patients with a high suspicion of viral pneumonia: such as acute onset during a season of high viral incidence, normal or low blood leukocyte counts, rapid disease progression, negative results for respiratory viral multiplex PCR testing and cultures; Immunocompromised patients: experiencing respiratory infections or severe illness.
3. Sufficient samples can be obtained.
4. Patients with complete clinical data.
Exclusion Criteria:
1. Refusal to sign informed consent.
2. Testing has clearly excluded infection.
3. Received antibiotic treatment within three days prior to testing without stopping the medication for more than 12 hours.
4. Sample quality is not up to standard.
5. Unable to obtain sufficient sample.
6. No complete drug usage history.
Primary outcome measure(s)
Comparison the results of the microbial detection rates of mNGS and tNGS、the number of strains detected and the type number of species detected — The time from the enrollment test to the result ,usually within 48 hours
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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