High-Resolution CT for Heart

Condition(s) studied

Investigational drug(s) / intervention(s)

Angiography based RWS and OCT based plaque characteristcis: Angiography based RWS and OCT based plaque characteristcis

Study summary

This prospective observational study aims to evaluate a high-resolution coronary CT platform (uCT SiriuX Pro) for non-invasive assessment of coronary plaque biomechanics and functional physiology in high-risk patients. The system enables CT-derived radial wall strain (CT-RWS), a novel biomarker reflecting plaque vulnerability, with potential correlation to invasive OCT findings and clinical outcomes.

The study will assess the diagnostic performance and prognostic value of CT-RWS, along with a new CT-based index of systolic flow perfusion (CT-SFPR) for evaluating the hemodynamic relevance of myocardial bridging, compared to nuclear perfusion imaging. Additionally, left ventricular ejection fraction derived from dynamic CTA (CT-EF) will be compared with echocardiography to evaluate its feasibility and accuracy. This is the first study to comprehensively validate CT-RWS, CT-SFPR, and CT-EF using a fully non-invasive, high-temporal-resolution CT platform.

Eligibility

Primary outcome measure(s)

• correlation between CT-RWS and Angiography-derived RWS/OCT-detected vulnerable plaque features — Perioperative/Periprocedural
  We will measure the RWS derived from coronary CT angiography (CT-RWS). After patients undergo coronary angiography and OCT examinations, we will also measure the angiography-derived RWS, both expressed as percentages. Correlation analyses will be performed to investigate the association between CT-RWS and angiography-derived RWS. In addition, OCT plaque characteristics, including thin-cap fibroatheroma, lipidic plaque burden, and lipid-to-cap ratio, will be assessed. Correlation analyses will be conducted to explore the relationships between CT-RWS and these OCT-derived plaque characteristics.

Trial sites (1)

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