Evaluation of ICP-B794 in Patients With Advanced Solid Tumors

Inclusion Criteria: 1. Age ≥18 years and ≤75 years. 2. Histologically confirmed other locally advanced or metastatic solid tumors. 3. Life expectancy ≥3 months. 4. Adequate organs function within 7 days prior to the first dose of ICP-B794 5. Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of 0 or 1。 6. At least one measurable lesion per RECIST V1.1 criteria. 7. Able to provide archived tumor tissue sample (within 2 years) or fresh tumor tissue sample. 8. Female participants of childbearing potential (WOCBP) must have a negative serum pregnancy test at screening. 9. WOCBP and male participants must agree to use contraceptive method. 10. Female participants must not breastfeed or plan pregnancy during the study and for at least 6 months after the last dose of investigational drug. 11. Participants must be able to communicate effectively with investigators and comply with all study requirements. 12. Participants voluntarily joined the study and signed the informed concent form (ICF). Exclusion Criteria: 1. Other active primary malignancies within 3 years prior to the first dose of investigational product. 2. Prior or current treatment with the similar drug or related treatment specified in the protocol. 3. Having a past medical history and unhealthy lifestyle history as specified in the protocol, or suffering from diseases as specified in the protocol. 4. Toxicities from prior anti-tumor therapy not recovered to ≤ Grade 1 (per CTCAE V5.0). 5. Major arterial or venous thrombotic events within 3 months prior to first dose. 6. Active bleeding within 2 months prior to screening or history of clinically significant bleeding tendency. 7. Major surgery within 28 days prior to first dose or minor surgery within 2 weeks prior to first dose. 8. Requirement for systemic corticosteroid therapy within 14 days prior to first dose. 9. History of severe hypersensitivity, or known severe hypersensitivity to the active pharmaceutical ingredient, inactive ingredients in the drug product, or antibody-based drugs, or hypersensitivity to recombinant human or murine proteins, or history of severe infusion reaction. 10. Administration of any live vaccine within 4 weeks prior to first dose or history of hypersensitivity reactions of any grade. 11. Female participants who are pregnant, lactating, or planning pregnancy during the study. 12. Any psychiatric or cognitive disorder that may impair understanding or execution of the informed consent document and/or protocol compliance 13. Other conditions determined by the investigator that render patients unsuitable for participation in this study.