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Clinical Trials in China / NCT07099157
Recruiting Phase 4

Efficacy and Safety of Brivudine in the Treatment of Herpes Zoster

NCT07099157 · tracked via the Priya Life Science China tracker
Sponsor
Peking University Third Hospital
Phase
Phase 4
Started
2025-08-25
Last updated
2026-01-02

Condition(s) studied

Herpes Zoster

Investigational drug(s) / intervention(s)

BrivudineFamciclovir

Brivudine: brivudine 125 mg per dose, once daily, 7 days

Famciclovir: orally receive famciclovir at doses adjusted based on creatinine clearance (CrCl), 7 days

Study summary

This multicenter RCT aims to compare the efficacy and safety of Brivudine versus Famciclovir in treating acute herpes zoster. Primary objective: Evaluate pain reduction via Numeric Pain Rating Scale (NPRS) at Day 30. Secondary objectives: Compare NPRS at Day 3/Day 7/Day 14/Day 90, time to lesion resolution, Postherpetic Neuralgia (PHN) incidence, and safety.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Age ≥18 years, regardless of gender; 2. Signed Informed Consent Form; 3. Female subjects must not plan for pregnancy or oocyte donation from screening until 1 week after the last dose and must voluntarily adopt highly effective physical contraception; male subjects must not plan for fertility or sperm donation during the same period and must voluntarily adopt highly effective physical contraception. Methods include: * Barrier methods: Condom or barrier cap (diaphragm or cervical cap); * Intrauterine device (IUD) or intrauterine system (IUS); * Surgical sterilization (bilateral oophorectomy with/without hysterectomy, total hysterectomy, bilateral tubal ligation, or vasectomy) performed ≥6 months prior to the first dose in the subject or their partner; * Other investigator-confirmed highly effective physical contraception. Exclusion Criteria: 1. Allergy to brivudine, famciclovir, or penciclovir; 2. Current use of fluorouracil agents (e.g., 5-fluorouracil, capecitabine, tegafur, flucytosine); 3. Cancer patients currently undergoing chemotherapy; 4. Pregnant or lactating women; 5. Parkinson's disease; 6. Any condition deemed inappropriate for study participation by the investigator.

Primary outcome measure(s)

Trial sites (4)

FacilityCityRegionStatus
Peking University Third Hospital Beijing China Recruiting
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing China Recruiting
Peking University First Hospital Beijing China Recruiting
Xuanwu Hospital, Capital Medical University Beijing China Not Yet Recruiting

More Peking University Third Hospital trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07099157 on ClinicalTrials.gov ↗ ← All trials in China