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Clinical Trials in China / NCT07073417
Active, not recruiting Phase 2

A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)

NCT07073417 · tracked via the Priya Life Science China tracker
Sponsor
Hangzhou Sciwind Biosciences Co., Ltd.
Phase
Phase 2
Started
2025-07-28
Last updated
2026-04-13

Condition(s) studied

ObesityWeight Management

Investigational drug(s) / intervention(s)

XW003 injectionsemaglutide injection

XW003 injection: Subcutaneous injection

semaglutide injection: Subcutaneous injection

Study summary

The aim of the study is to compare the efficacy and safety of XW003 injection versus semaglutide injection in Chinese adults with obesity

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * BMI≥30 kg/m2 at screening, waist circumference ≥90 cm for men and ≥85 cm for women. * Weight change of less than 5% within 3 months prior to screening (self-reported). Exclusion Criteria: * Diagnosis of obesity due to endocrine disorders or a single gene mutation, including but not limited to hypothalamic obesity, pituitary obesity, Cushing's syndrome, hypothyroidic obesity (except for those with normal thyroid function at screening and expected to remain unchanged throughout the trial period after at least 3 months of thyroid hormone replacement therapy), insulinoma, acromegaly. * History of bariatric surgery or planning to undergo bariatric surgery or use other weight-loss drugs or devices during the trial (except acupuncture for weight loss, liposuction, or abdominal fat removal for more than one year before screening; Except the removal or expulsion of the airbag in the stomach for more than 1 year before screening. * Diagnosis with any type of diabetes (except gestational diabetes). * Have used any weight-loss drugs, hypoglycemic drugs, or drugs that may cause significant weight gain within 3 months prior to screening. * History of acute or chronic pancreatitis or pancreatic injury, history of symptomatic gallbladder disease (except cholecystectomy). * History of clinically significant gastric emptying abnormalities, such as gastroparesis or gastric outlet obstruction.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Peking University People's Hospital Beijing Beijing Municipality

More Hangzhou Sciwind Biosciences Co., Ltd. trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07073417 on ClinicalTrials.gov ↗ ← All trials in China