Deep cervical lymphatic venous anastomosis: The intervention requires to perform bilateral deep cervical lymphatic venous anastomosis (DC-LVA). Through cervical incision, the deep cervical lymphatic tissue is anatomically dissected and anastomosed with the venous system of the neck. Under indocyanine green (ICG) navigation, the flow of lymphatic fluid into the vein could be observed via ICG tracing fluorescence after surgery.
Study summary
This multicenter, prospective registry is to evaluate the efficacy and safety of deep cervical lymphatic venous anastomosis (DC-LVA) in reduing the clinical dementia rating-sum of boxes (CDR-SB) score of Alzheimer's Disease (AD) patients at 12 months after surgery in the real-world.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Age ≥ 18 years, male or famale.
2. Diagnosed with AD according to the NIA-AA criteria.
3. Patients who have received DC-LVA treatment;
4. Signed informed consent (by the subject or their relative, and caregiver)
Exclusion Criteria:
1. Severe neurological deficits in limb movement, language, vision, hearing, or consciousness, or any condition that the investigator determines may prevent the completion of cognitive function assessments.
2. The subject lacks a stable and reliable caregiver to accompany with them during entire study follow-up visits.
Primary outcome measure(s)
The change of Clinical Dementia Rating-Sum of Boxes score at 12th months after surgery — From baseline to 12th months after surgery The change of Clinical Dementia Rating-Sum of Boxes score (CDR-SB, 0-18 score, higher scores mean a worse outcome)
The incidence of perioperative complications within 7 days after surgery — From baseline to 7th days after surgery The incidence of perioperative complications
Trial sites (1)
Facility
City
Region
Status
Beijing Tiantan Hopital, Capital Medical University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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