The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM

Condition(s) studied

Study summary

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

Eligibility

Primary outcome measure(s)

• characteristics of flow-related aneurysm — From enrollment to the end of treatment at 8 weeks
  size ratio(aneurysm depth (mm)/parent artery diameter (mm))

Trial sites (2)

More The First Affiliated Hospital with Nanjing Medical University trials in China