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Clinical Trials in China / NCT07042802
Recruiting Phase 1/2

A Study of LBL-024 in Combination With Paclitaxel ± Bevacizumab for the Treatment of Platinum-resistant Ovarian Cancer

NCT07042802 · tracked via the Priya Life Science China tracker
Sponsor
Nanjing Leads Biolabs Co.,Ltd
Phase
Phase 1/2
Started
2025-12-02
Last updated
2026-08-13

Condition(s) studied

Ovarian Cancer

Investigational drug(s) / intervention(s)

LBL-024 for InjectionPaclitaxel injectionBevacizumab injection

LBL-024 for Injection: Intravenous infusion.

Paclitaxel injection: Intravenous infusion.

Bevacizumab injection: Intravenous infusion.

Study summary

This study is an open-label, multicenter Phase Ib/II clinical trial of LBL-024 in combination with other drugs for the treatment of patients with platinum-resistant ovarian cancer (OC), aiming to evaluate the efficacy and safety of LBL-024 in combination with other drugs in the treatment of advanced recurrent platinum-resistant ovarian cancer (OC).

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Agree to follow the trial treatment regimen, visit schedule, laboratory test, and other requirements of the protocol, and voluntarily enroll in the study and sign the written informed consent. 2. At the time of signing the informed consent form, the age was ≥ 18 years old. 3. The Eastern Cooperative Oncology Group's physical status scoring standard (ECOG) is 0\~1. 4. The expected survival time is at least 12 weeks. 5. According to the evaluation of RECIST 1.1 (Response Evaluation Criteria in Solid Tumours),the Participants enrolled have at least one measurable lesion. 6. Females of childbearing age are willing to take highly effective contraceptive measures From the signing of the informed consent form to within 6 months after the last administration of the trial drug;Women of childbearing age include pre-menopausal women and women within 2 years after menopause. Women of childbearing age must have a negative pregnancy test within 7 days before the first trial drug is administered. Exclusion Criteria: 1. The Participants is currently participating in any other clinical trial,Or has received or is receiving other investigational agents within 4 weeks prior to the first dose of study drug. 2. Use of immunomodulatory drugs within 2 weeks prior to the first use of study drug. 3. Participants with active infection and currently requiring systemic treatment. active pulmonary tuberculosis (TB), receiving anti-tuberculosis treatment or Received anti-tuberculosis treatment within 6 months before screening. 4. Participants with clinically uncontrollable pleural effusion, pericardial effusion or ascites, and those requiring repeated drainage or medical intervention. 5. The Participants has a Medical history of immunodeficiency, including HIV antibody positive. 6. Active hepatitis B or active hepatitis C. 7. Women during pregnancy or lactation. 8. History of mental and/or psychiatric illness (impairing understanding or giving informed consent), drug abuse, alcoholism, or drug addiction. 9. The investigator believes that the Participants has other conditions that may affect compliance or are not suitable for participating in this study.

Primary outcome measure(s)

Trial sites (13)

FacilityCityRegionStatus
Cancer Institute and Hospital, Chinese Academy of Medical Sciences Beijing Beijing Municipality Recruiting
Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Beijing Municipality Not Yet Recruiting
Fujian Cancer Hospital Fuzhou Fujian Not Yet Recruiting
Sun Yat-sen University Cancer Center Guangzhou Guangdong Not Yet Recruiting
Harbin Medical University Cancer Hospital Harbin Heilongjiang Not Yet Recruiting
AnYang Tumor Hospital Anyang Henan Recruiting
The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Not Yet Recruiting
The Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu Recruiting
The First Hospital of China Medical University Shenyang Liaoning Recruiting
Shandong Cancer Hospital Jinan Shandong Recruiting
Tianjin Medical University Cancer Institute &Hospital Tianjin Tianjin Municipality Recruiting
Yunnan Cancer Hospital Kunming Yunnan Recruiting
Zhejiang Cancer Hospital Hangzhou Zhejiang Recruiting

More Nanjing Leads Biolabs Co.,Ltd trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07042802 on ClinicalTrials.gov ↗ ← All trials in China