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Recruiting Observational

The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP

NCT07030179 · tracked via the Priya Life Science China tracker
Sponsor
Phase
Observational
Started
2025-07-01
Last updated
2026-04-02

Condition(s) studied

Postoperative Acute Kidney InjuryFrailty

Investigational drug(s) / intervention(s)

Frailty status

Frailty status: This was an observational study with no intervention measures. The exposure factor was the frailty status of the patients.

Study summary

The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * 18 years old or above * Undergo non-cardiac surgery Exclusion Criteria: * At least one measurement of serum creatinine (SCr) was not conducted before and after the operation * End-stage renal disease (ESRD) that has received dialysis within the past year * Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients) * Acute kidney injury occurred within 7 days before the operation * No frailty assessment was conducted * The surgical procedure is renal surgery * The operation time is less than 2 hours

Primary outcome measure(s)

  • Postoperative acute kidney injury — Within one week after the operation

Trial sites (1)

FacilityCityRegionStatus
Zhongda Hospital Southeast University Nanjing Jiangsu Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07030179 on ClinicalTrials.gov ↗ ← All trials in China