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Clinical Trials in China / NCT07010263
Recruiting Phase 3

A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy

NCT07010263 · tracked via the Priya Life Science China tracker
Sponsor
Akeso
Phase
Phase 3
Started
2025-06-13
Last updated
2026-03-05

Condition(s) studied

Small Cell Lung Cancer

Investigational drug(s) / intervention(s)

AK112Placebo

AK112: AK112 20mg/kg, intravenous \[IV\]),Q3W

Placebo: Placebo, intravenous \[IV\]),Q3W

Study summary

This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK112 to placebo as consolidation treatment for patients with limited stage small cell lung cancer who have not progressed following concurrent chemoradiation therapy.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: Inclusion Criteria: 1. The subjects voluntarily participated in the study with full informed consent and signed written informed consent form. 2. Aged ≥18 years on day fo signing the informed consent. 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. 4. Life expectancy ≥ 3 months 5. Histologically or cytologically confirmed small cell lung cancer. 6. Documented limited-stage SCLC (Stage I-III SCLC \[T any, N any, M0\] according to the American Joint Committee on Cancer Staging Manual \[AJCC Cancer Staging Manual, 8th Edition\] or the Veterans Administration Lung Study Group (VALG) stage. 7. Have Received concurrent chemoradiotherapy regimen as defined in protocol and have not progressed following concurrent chemoradiotherapy. 8. Adequate organ function. 9. Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to the first dose and agree to take effective contraception measures during the study drug administration and within 120 days after the last dose. Exclusion Criteria: 1. Histologically or cytological confirmed the presence of mixed small cell lung cancer or non-small cell lung cancer components. 2. Toxicities from previous anti-tumor treatments have not resolved to grade 0 or 1 based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE v5.0), or to the levels specified in inclusion/exclusion criteria, except for alopecia. 3. Symptoms or signs of primary disease deterioration that the investigator judges clinically unacceptable, such as cachexia. 4. Presence of pleural effusion, pericardial effusion, or ascites, which was clinically symptomatic or requiring frequent drainage. 5. History of active malignant tumors within the previous 5 years. 6. Received major surgery within 28 days prior to the first dose of study drug, or expected to undergo major surgery during the study period within 28 days after the first dose of study drug. 7. Uncontrolled comorbidities, including but not limited to decompensated cirrhosis, nephrotic syndrome, uncontrolled metabolic disorders, severe active peptic ulcer disease or gastritis, and other related diseases.. 8. Have serious neurological or mental illnesses, including dementia and epileptic seizures. 9. Pregnant or lactating women. 10. Have cardiovascular or cerebrovascular diseases or risk factors. 11. Prior treatments with systemic non-specific immunomodulatory therapy (such as interleukin, interferon, thymosin, etc.) within 2 weeks before the first administration of the study drugs. Prior treatment with Chinese herbal medicine or traditional Chinese patent medicines with anti-tumor indications within 1 weeks before the first administration of the study drugs. 12. Prior treatments targeting immune mechanisms, including, but not limited to, immune checkpoint inhibitors, immune checkpoint agonists, immune cell therapy. 13. Prior treatments with anti-angiogenic therapy. 14. Subjects requiring systemic treatment with corticosteroids (\>10mg/day prednisone or equivalent dose) or other immunosuppressive drugs within 14 days prior to the first dose of study drug. 15. Known history of severe hypersensitivity reactions to other monoclonal antibodies or with a known history of allergy or hypersensitivity reactions to any of study drugs or their components. 16. Active autoimmune diseases that require systemic treatment within 2 years prior to the study, or autoimmune diseases that the investigator judges to be potentially recurrent or require planned treatment. 17. Known interstitial lung disease or non infectious pneumonia, which currently has symptoms or requires systemic corticosteroid treatment in the past,or investigator juges may affect the toxicity assessment or management related to the study treatment. 18. Known severe infection within 4 weeks prior to the first dose of study drug. Known active tuberculosis. Known active syphilis infection. Known history of immunodeficiency or positive HIV test results. 19. .Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation. 20. Active hepatitis B or active hepatitis C. 21. Received a live vaccine within 30 days prior to the first dose of study drug, or planning to receive a live vaccine during the study period.

Primary outcome measure(s)

Trial sites (53)

FacilityCityRegionStatus
Beijing Cancer Hospital Beijing Beijing Municipality Recruiting
The First Medical Center of Chinese PLA General Hospital Beijing Beijing Municipality Recruiting
Beijing Chest Hospital Beijing Beijing Municipality Recruiting
Beijing Luhe Hospital, Capital Medical University Beijing Beijing Municipality Recruiting
Cancer Hospital, Chinese Academy of Medical Sciences Beijin Beijin Recruiting
The First Affiliated Hospital of Chongqing Medical University Chongqing Chongqing Municipality Recruiting
Fujian Cancer Hospital Fuzhou Fujian Recruiting
PLA No. 900 Hospital of the Joint Support Force Fuzhou Fujian Recruiting
Longyan First Hospital Longyan Fujian Recruiting
Zhangzhou Municipal Hospital of Fujian Province Zhangzhou Fujian Recruiting
Gansu Provincial Cancer Hospital Lanzhou Gansu Recruiting
Jiangmen Central Hospital Jiangmen Guangdong Recruiting
Liuzhou People's Hospital Liuzhou Guangxi Recruiting
Affiliated Cancer Hospital of Guangxi Medical University Nanning Guangxi Recruiting
The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi Recruiting
Guangdong Provincial People's Hospital Guangzhou Guangzhou Recruiting
Guizhou Provincial People's Hospital Guiyang Guizhou Recruiting
The Second Affiliated Hospital of Zunyi Medical University Zunyi Guizhou Recruiting
The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei Recruiting
Tangshan People's Hospital Tangshan Hebei Recruiting
Harbin Medical University Cancer Hospital Harbin Heilongjiang Recruiting
The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang Recruiting
Anyang Cancer Hospital Anyang Henan Recruiting
The First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan Recruiting
Henan Cancer Hospital Zhengzhou Henan Recruiting
Jingzhou First People's Hospital Jingzhou Hubei Recruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei Not Yet Recruiting
Hunan Cancer Hospital Changsha Hunan Recruiting
Hunan Cancer Hospital Changsha Hunan Recruiting
The First Affiliated Hospital of South China University Hengyang Hunan Recruiting
General Hospital of the PLA Eastern Theater Command Nanjing Jiangsu Recruiting
Jiangsu Cancer Hospital Nanjing Jiangsu Recruiting
Xuzhou Municipal Hospital Xuzhou Jiangsu Recruiting
The First Affiliated Hospital of Gannan Medical University Gannan Jiangxi Recruiting
The First Affiliated Hospital of Nanchang University Nanchang Jiangxi Recruiting
Jilin Cancer Hospital Changchun Jilin Recruiting
The First Hospital of China Medical University Shenyang Liaoning Recruiting
Ningxia Medical University General Hospital Yinchuan Ningxia Recruiting
Shandong Provincial Hospital Jinan Shandong Recruiting
Shandong Cancer Hospital Jinan Shandong Recruiting

+ 13 more sites — see the full list on the official registry below.

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Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07010263 on ClinicalTrials.gov ↗ ← All trials in China