Ticagrelor + Aspirin for 3 Months (followed by aspirin monotherapy): Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, followed by aspirin monotherapy
Ticagrelor + Aspirin for 6 Months (followed by aspirin monotherapy): Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 6 months, followed by aspirin monotherapy
Ticagrelor + Aspirin for 12 Months (followed by aspirin monotherapy): Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 12 months, followed by aspirin monotherapy
Study summary
This randomized controlled trial aims to evaluate the impact of different durations of Ticagrelor-based dual antiplatelet therapy (DAPT) on saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass grafting (CABG). A total of 300 patients will be randomly assigned to receive Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, 6 months, or 12 months, followed by aspirin monotherapy.The primary outcome is 1-year graft patency, assessed via coronary CT angiography. Secondary outcomes include bleeding events (BARC classification), major adverse cardiovascular and cerebrovascular events (MACCE), and all-cause mortality. The study aims to determine the optimal DAPT duration to balance graft patency benefits and bleeding risks, ultimately guiding postoperative antiplatelet strategies for CABG patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Patients 18-80 of age.
2. Patients undergo planned CABG for the first time with ≥1 SVGs
3. Patients with written informed consent.
Exclusion Criteria:
1. Patients undergoing concomitant valve surgery (excluding aortic bioprosthesis), aortic surgery, or rhythm surgery during the same session.
2. Patients undergoing emergency CABG.
3. Patients with single-vessel coronary artery disease.
4. Patients with cardiogenic shock or hemodynamic instability.
5. Patients with sick sinus syndrome, second- or third-degree atrioventricular block.
6. Patients with contraindications for coronary computed tomography angiography (CCTA) or coronary angiography, including contrast media allergy.
7. Patients requiring antiplatelet therapy other than aspirin or ticagrelor (e.g., clopidogrel, prasugrel) and unable to discontinue such medication after CABG, based on physician or investigator judgment.
8. Patients on oral anticoagulants before CABG who must continue anticoagulation therapy postoperatively.
9. Patients with contraindications for ticagrelor or aspirin, including:
9.1Bleeding diathesis within the past 3 months. 9.2Severe gastrointestinal bleeding within the past year. 9.3Peptic ulcer (even without bleeding) within the past 3 years. 9.4History of intracranial hemorrhage, aspirin allergy, or severe aspirin-induced gastrointestinal reaction.
10. Patients with a drug-eluting stent (DES) in a coronary or cerebral artery within 6 months before CABG, or a bare-metal stent (BMS) within 1 month before CABG.
11. Patients with thrombocytopenia (\<100 x 10⁹/L) before CABG.
12. Patients with severe renal dysfunction requiring dialysis or active liver disease, including unexplained persistent transaminase elevation or transaminase levels \>3× the upper normal limit.
13. Patients using strong CYP3A4 inhibitors.
14. Patients requiring methotrexate and ibuprofen therapy.
15. Patients with active malignant tumors with an increased risk of bleeding, as determined by the investigator.
16. Pregnant or breastfeeding women, and those who have given birth within the past 90 days.
17. Premenopausal women not using adequate contraception. Adequate contraception requires at least two reliable methods, including one barrier method.
Primary outcome measure(s)
Saphenous Vein Graft (SVG) Patency at 12 Months — 12 months post-CABG SVG patency will be assessed using coronary CT angiography, defined as FitzGibbon Grade A (≤50% stenosis). The patency rates will be compared among the three groups receiving Ticagrelor-based DAPT for different durations (3 months, 6 months, or 12 months).
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.