a2 UHT milk: Pregnant women in this arm will drink a2 UHT Milk twice a day, 200ml each time, until study completion. Their infants will be fed with the mother's breastmilk exclusively.
Conventional UHT Milk: Pregnant women in this arm will drink conventional UHT Milk twice a day, 200ml each time, until study completion. Their infants will be fed with the mother's breastmilk exclusively.
Study summary
The aim of the study is to compare the effects of conventional Ultra High Temperature (UHT) milk containing both A1 and A2 type β-caseins (CON) with a2 UHT Milk containing A2 type β-casein only (A1PF) on inflammation, tolerance, and GI symptoms in pregnant women as well as infants' birth outcomes from 12 weeks' gestation up to 40 days post-birth.
Eligibility
Sex
FEMALE
Min age
20 Years
Max age
35 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* 20-35 years of age
* Recruited at \<12 weeks of gestation
* Intention to deliver at study site hospital
* Singleton pregnancy
* Able and willing to consume milk during pregnancy
* Agree not to participate in another interventional clinical study during the present study
Exclusion Criteria:
* Body mass index ≥ 35 at enrolment
* Cow's milk intolerance or allergy
* Significant systemic disorder (e.g., cardiac, respiratory, endocrinological, hemato-logic, or GI); pre-pregnancy diabetes, hypertension, or other medical conditions that preclude participation per the investigator's judgement
* Taking any prescribed chronic medications
* Participation in another clinical trial
* Investigator uncertainty about the willingness or ability of the participant to comply with the protocol requirements
* Taking probiotics at screening or two weeks before enrolment
* Receiving any vaccine at screening or two weeks before enrolment
Primary outcome measure(s)
GI tolerance — Visit 1 (baseline, 12 weeks' gestation) GI tolerance via the GSRS questionnaire
GI tolerance — Visit 2 (24 weeks' gestation) GI tolerance via the GSRS questionnaire
GI tolerance — Visit 3 (36 weeks' gestation) GI tolerance via the GSRS questionnaire
GI tolerance — Visit 4 (40 days after delivery) GI tolerance via the GSRS questionnaire
Panyu Maternal and Child Care Service Centre of Guangzhou
Guangzhou
Guangdong
Wuxi Maternal and Child Health Hospital
Wuxi
Jiangsu
Affiliated hospital of Jiangnan University
Wuxi
Jiangsu
Xuzhou Maternal and Child Health Hospital
Xuzhou
Jiangsu
First People's Hospital of Chengdu
Chengdu
Sichuan
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.