🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in China / NCT06973187
Recruiting Phase 3

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187 · tracked via the Priya Life Science China tracker
Sponsor
BeOne Medicines
Phase
Phase 3
Started
2025-09-04
Last updated
2026-09-11

Condition(s) studied

Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma

Investigational drug(s) / intervention(s)

TacabrutidegPirtobrutinib

Tacabrutideg: Tacabrutideg will be administered orally

Pirtobrutinib: Pirtobrutinib will be administered orally

Study summary

The purpose of this study is to evaluate the efficacy and safety of tacabrutideg alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase inhibitor (cBTKi).

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Confirmed diagnosis of CLL or SLL, requiring treatment, based on 2018 iwCLL criteria * Previously received treatment for CLL/SLL with a covalent Bruton tyrosine kinase inhibitor (cBTKi). Patients should have disease relapsed after or refractory to at least 1 line of therapy including a cBTKi. * Participants with SLL must have measurable disease by computed tomography/magnetic resonance imaging, defined as ≥ 1 lymph node \> 1.5 cm in longest diameter and measurable in 2 perpendicular diameters. Exclusion Criteria: * Known prolymphocytic leukemia or history of, or currently suspected, Richter's transformation. * History of known bleeding disorder such as hemophilia A, hemophilia B, von Willebrand disease, or history of spontaneous bleeding requiring blood transfusion or other medical intervention * History of ischemic stroke or intracranial hemorrhage within 6 months before first dose of study drug * Prior exposure to any Bruton tyrosine kinase (BTK) protein degraders or noncovalent Bruton tyrosine kinase inhibitor (ncBTKi). * Current or history of central nervous system involvement including the brain, spinal cord, leptomeninges, and cerebrospinal fluid (as documented by imaging, cytology, or biopsy) by CLL/SLL NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcome measure(s)

Trial sites (214)

FacilityCityRegionStatus
University of Alabama At Birmingham Hospital Birmingham Alabama Recruiting
Mayo Clinic Phoenix Phoenix Arizona Recruiting
Kaiser Permanente Southern California Irvine California Recruiting
University of California San Diego (Ucsd) Moores Cancer Center La Jolla California Recruiting
Cancer and Blood Specialty Clinic Los Alamitos California Recruiting
UCLA Department of Medicine Hematologyoncology Los Angeles California Recruiting
Kaiser Permanente Oakland Medical Center Oakland California Recruiting
Stanford Cancer Institute Palo Alto California Recruiting
Kaiser Permanente Roseville Medical Center Roseville California Recruiting
Kaiser Permanente San Francisco Medical Center Oncology San Francisco California Recruiting
Kaiser Permanente Santa Clara Medical Center Oncologyhematology Santa Clara California Recruiting
Kaiser Permanente Northern California Vallejo California Recruiting
Kaiser Permanente Walnut Creek Medical Center Walnut Creek California Recruiting
Christiana Care Newark Delaware Recruiting
Medstar Georgetown University Hospital Washington D.C. District of Columbia Recruiting
Mayo Clinic Jacksonville Jacksonville Florida Recruiting
Cancer Specialists of North Florida Jacksonville Florida Recruiting
Mount Sinai Medical Center Braman Comprehensive Cancer Center Miami Florida Recruiting
University of Chicago Medical Center Chicago Illinois Recruiting
Mission Cancer and Blood Waukee Iowa Recruiting
The University of Kansas Cancer Center Westwood Kansas Recruiting
Our Lady of the Lake Hospital Baton Rouge Louisiana Recruiting
Mary Bird Perkins Cancer Center Baton Rouge Louisiana Recruiting
Ochsner Clinic Foundation New Orleans Louisiana Recruiting
Dana Farber Cancer Institute Boston Massachusetts Recruiting
Karmanos Cancer Institute Detroit Michigan Recruiting
Mayo Clinic Rochester Rochester Minnesota Recruiting
Washington University School of Medicine St Louis Missouri Recruiting
Titan Health Partners Llc Dba Astera Cancer Care East Brunswick New Jersey Recruiting
John Theurer Cancer Center Hackensack University Medical Center Hackensack New Jersey Recruiting
Columbia University Medical Center New York New York Recruiting
Weill Cornell Medical College Newyork Presbyterian Hospital New York New York Recruiting
Memorial Sloan Kettering Cancer Center Mskcc New York New York Recruiting
University of Rochester Rochester New York Recruiting
University of North Carolina At Chapel Hill Chapel Hill North Carolina Recruiting
Atrium Health Levine Cancer Institute (Lci) Charlotte North Carolina Recruiting
Duke University Medical Center Durham North Carolina Recruiting
Atrium Health Wake Forest Baptist Winston-Salem North Carolina Recruiting
Dayton Physician Network Dayton Ohio Recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania Recruiting

+ 174 more sites — see the full list on the official registry below.

More BeOne Medicines trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06973187 on ClinicalTrials.gov ↗ ← All trials in China