Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics

NCT06967285 · tracked via the Priya Life Science China tracker

Sponsor

Sichuan Provincial People's Hospital

Phase

Observational

Started

2025-03-19

Last updated

2025-05-13

Condition(s) studied

ARDS (Moderate or Severe)

Investigational drug(s) / intervention(s)

Prone ventilation

Prone ventilation: Cerebral Blood Flow Monitoring Before and After Prone Ventilation in Patients with ARDS.Cerebral blood flow,intracranial pressure,and systemic hemodynamic monitoring were performed at the following time points:before prone positioning(T0),1 hour after prone ventilation(T1),12 hours after prone ventilation(T2),1 hour after returning to the supine position(T3),and 7 days after returning to the supine position(T4).

Study summary

Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age≥18 years * Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation * Expected duration of mechanical ventilation\>48 hours * Written informed consent obtained Exclusion Criteria: * Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension) * Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics * Life-threatening ARDS * Patients who are unable to undergo neurological assessment * Poor image quality or absence of images

Primary outcome measure(s)

Neuroimaging Studies — From enrollment to 2 weeks after the end of treatment.
Cranial CT or MRI Scans Conducted Before and After Prone Positioning to Detect New-Onset Neurological Complications Such as Cerebral Edema, Intracranial Hemorrhage, and Cerebral Infarction
Biomarker Detection — From enrollment to 2 weeks after the end of treatment.
Blood samples were collected for NSE(Neuron-specific Enolase)and IL-6(Interleukin-6)before and after prone positioning.

Trial sites (1)

Facility	City	Region	Status
Sichuan Provincial People's Hospital,	Chengdu	Sichuan	Recruiting

More Sichuan Provincial People's Hospital trials in China

Efficacy and Safety of Amphotericin B and Azoles in the Treatment of Invasive Fungal Disease Recruiting

[18F]AV45(Aβ) and [18F]AV1451(Tau)PET/CT in the Diagnosis of Early Pathological Changes of Alzheimer's Disease Recruiting

Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery Starting soon

Mechanism of Red Yeast Rice Regulating Intestinal Indole Metabolism Pathway to Improve Chronic Inflammation in Polycystic Ovary Syndrome Recruiting

Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds Starting soon

Other trials for the same condition

A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome Recruiting

The PRE-VAIL Study Recruiting

Effect of Inhaled Nitric Oxide Therapy in Adults With Moderate-to-Severe Acute Respiratory Distress Syndrome Starting soon

Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06967285 on ClinicalTrials.gov ↗ ← All trials in China