Generalized Anxiety Disorder (GAD)InsomniaRepetitive Transcranial Magnetic Stimulation (rTMS)
Investigational drug(s) / intervention(s)
Repetitive Transcranial Magnetic StimulationSham Repetitive Transcranial Magnetic Stimulation
Repetitive Transcranial Magnetic Stimulation: Repetitive transcranial magnetic stimulation (rTMS) can noninvasively modulate cortical activity by delivering a sequence of magnetic pulses.
Sham Repetitive Transcranial Magnetic Stimulation: Sham tDCS was delivered using the same protocol and current intensity, but it is carried out as the coil is turned away from the skull at 90°.
Study summary
To investigate the intervention effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on insomnia symptoms of generalized anxiety disorder patients.
Eligibility
Sex
ALL
Min age
15 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
1. age between 15 and 65 years;
2. clinically diagnosed with anxiety according to the Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V);
3. no previous application of any insomnia pharmacological therapy for at least one week before baseline visit.
Exclusion Criteria:
1. current or history of serious brain and body diseases;
2. current or history of schizophrenia, behavioral problems, post-traumatic stress disorder, mania, obsessive-compulsive disorder, and social phobia;
3. substance abuse or other comorbid psychological diseases.
Primary outcome measure(s)
subjective sleep quality assessed by the PSQI — before and after 10-day intervention and at 1-month follow-up The Pittsburgh Sleep Quality Index (PSQI) consist of 18 items divided into 7 dimensions, such as sleep duration, sleep efficiency, sleep disorders and daytime dysfunction. The PSQI total score ranges from 0 to 21, the higher the score indicates the more worse sleep quality.
subjective sleep quality assessed by the ISI — before and after 10-day intervention and at 1-month follow-up The Insomnia Severity Index (ISI) is a 7-item scale to measure insomnia symptoms, where each item is rated on a scale from 0 to 4. The ISI total score ranges from 0 to 28, The higher the score indicates the more worse sleep quality.
emotional symptoms assessed by the HAMA — before and after 10-day intervention and at 1-month follow-up The HAMA is a 14-item scale to measure the severity of anxiety symptoms, where each item is rated on a scale from 0 to 4. The HAMA total score ranges from 0 to 56, with lower scores indicating less anxiety symptoms.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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