A Study to Evaluate Efficacy and Safety of HS-10374 for Mild-to-moderate Plaque Psoriasis

Inclusion Criteria: 1. Male or female subjects between the ages of 18-70 years 2. Diagnosis of plaque psoriasis for at least 6 months 3. sPGA score of 2-3, BSA 2-15%, PASI score 2-15 4. Subject must be inadequately controlled with, or intolerant of at least one topical therapy Exclusion Criteria: 1. Diagnosis of non-plaque psoriasis or drug-induced psoriasis 2. Recent history of infection, history or risk of serious infection 3. Any major illness or evidence of unstable condition of major organ systems including psychiatric disease 4. Any condition possibly affecting the PK process of the study drug 5. Evidence of other skin conditions that would interfere with the evaluation of psoriasis 6. History of hypersensitivity to the ingredients of study drugs, history of anaphylaxis 7. Prior exposure to TYK2 inhibitors 8. Have received the prohibited treatment during the protocol required washout period 9. Any significant laboratory or procedure abnormalities that might place the subject at unacceptable risk during this study period