The Effect of Exercise on Metabolic Alteration

Condition(s) studied

Investigational drug(s) / intervention(s)

Exercise intervention: Exercise prescription for participant， * 150Kcal for Weeks 1-4 (gradually increase to 150Kcal in the first two weeks as familiar stage), * 250Kcal for Weeks 5-8, * 350Kcal for Weeks 9-12.

Study summary

The goal of this clinical trial is to study the effectiveness of aerobic exercise in treating obesity in adults and to assess the efficacy of exercise. The primary research questions it seeks to address are as follows:

* To what extent does exercise increase the total energy expenditure of participants?
* Why and how does the energy expenditure from exercise not fully compensate for the total energy expenditure (TEE)?
* Researchers will assess the efficacy and potential challenges of using exercise as a treatment for obesity by comparing the measurement data before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).

Participants will engage in the following activities:

* Engage in running sessions supervised five times a week for a duration of 12 weeks.
* Attend laboratory sessions both before and after the exercise intervention period for metabolic and anthropometric measurements, as well as sample collection.
* Return to the laboratory for further metabolic and anthropometric measurements and sample collection8 weeks post-completion of exercise intervention.

Eligibility

Primary outcome measure(s)

• Change in TEE. — Three times, it takes 14 days for each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
  The change in TEE will be evaluated using the DLW method before and after exercise intervention.
• Change in TEF and REE. — Three times, it takes 1 days for each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
  The change in BEE and TEF will be measured through indirect calorimetry in a respiratory chamber.
• Change in exercise energy expenditure. — Three times, it takes 14 days for each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
  The change in exercise energy expenditure will be assessed using indirect calorimetry with a respiratory hood system (COSMED).
• Change in food intake. — Three times, food intake assessment takes 2 days: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
  Food intake will be assessed using a 2-day food record complemented by photographing and weighing the food before and after consumption.
• Change in physical activity. — Three times, it takes takes 14 days: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
  The physical activity levels of the participants will be monitored through the use of a GT3X accelerometer.

Trial sites (1)

More Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences trials in China

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