An Interpretable Fundus Diseases Report Generating System Based On Weakly Labelings

Condition(s) studied

Investigational drug(s) / intervention(s)

With fundus diseases: With fundus diseases

Without fundus diseases: Without fundus diseases

Study summary

To establish a multimodal fundus image report generation model to realize an interpretable system for multiple fundus diseases, multimodal image analysis, diagnosis, and treatment decision automatic reporting based on weakly labeled training data. Construct an interpretable feature fusion network for the clinical and imaging features of fundus lesions, and we hope to extract new imaging markers that can predict the occurrence and progression of various fundus lesions at an early stage, and ultimately verify them in real clinical data, further providing possible directions for exploring the molecular mechanisms of refractory fundus lesions, and may also provide new ideas for the precise prevention and treatment of fundus lesions.

Eligibility

Primary outcome measure(s)

• Fundus Fluorescein Angiography (FFA) images with corresponding report — Baseline
  Fundus Fluorescein Angiography(FFA) images with corresponding report were collected. FFA allows dynamic observation of changes in retinal blood vessels and lesions.
• Indocyanine Green Angiography (ICGA) images with report — Baseline
  Indocyanine Green Angiography (ICGA) images with corresponding report were collected. ICGA allows dynamic observation of changes in choroidal blood vessels and lesions.
• Fundus photography with corresponding report — Baseline
  Fundus photography images with corresponding report were collected. Fundus photography provides observation of morphological manifestations of the retina, the retinal blood vessels, the optic nerve, as well as lesions on the retina.
• Optical coherence tomography (OCT) images with corresponding report — Baseline
  Optical coherence tomography (OCT) images with corresponding report were collected. OCT images provides observation of changes in retinal thickness, morphology and manifestations of lesions in each retinal or choroidal layer, as well as lesions in the macular area and optic nerve
• Optical coherence tomography angiography (OCTA) images with corresponding report — Baseline
  Optical coherence tomography angiography (OCTA) images with corresponding report were collected. OCTA images provides observation of the density, morphology, and manifestations of retinal blood vessels, as well as the morphology and manifestations of retinal lesions

Trial sites (1)

More Zhongshan Ophthalmic Center, Sun Yat-sen University trials in China

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