🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in China / NCT06907043
Recruiting Phase 1/2

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

NCT06907043 · tracked via the Priya Life Science China tracker
Sponsor
Eikon Therapeutics
Phase
Phase 1/2
Started
2025-04-30
Last updated
2025-08-19

Condition(s) studied

Advanced Solid Tumors

Investigational drug(s) / intervention(s)

EIK1004-001 (IMP1707-001)

EIK1004-001 (IMP1707-001): PARP1 selective inhibitor

Study summary

This study will evaluate the safety, tolerability, and preliminary efficacy of EIK1004 (IMP1707) in participants with recurrent advanced/metastatic breast cancer, ovarian cancer, metastatic castrate resistant prostate cancer (mCRPC) and pancreatic cancer with deleterious/suspected deleterious mutations of select homologous recombination repair (HRR) genes.

Condition or disease Intervention/treatment Phase Advanced Solid Tumors Drug: EIK1004 (IMP1707) Phase 1/Phase 2

Eligibility

Sex
ALL
Min age
18 Years
Max age
89 Years
Healthy volunteers
No
• Breast cancer: must have received at least one prior chemotherapy in neoadjuvant/adjuvant/metastatic setting, must have received hormonal therapy if HR+, HGSOC or high grade endometrioid EOC, fallopian tube or primary peritoneal cancer; must have received at least one prior platinum-based chemotherapy for advanced disease. mCRPC with ongoing ADT, must have received NHA and up to 1 prior line of taxane chemotherapy; Pancreatic cancer, must have prior 1L therapy * Age ≥ 18 years at the time of informed consent * Eastern Cooperative Oncology Group (ECOG) performance status ≤1 * Adequate organ function * Life expectancy ≥ 12 weeks * Should have evaluable disease as defined by RECIST1.1 and/or CA125 or PSA * Female subjects of childbearing potential and male subjects must agree to use an effective method of contraception from study entry up to 6 months after the last dose of EIK1004 (IMP1707) * Deleterious or suspected deleterious germline or somatic mutations of select HRR genes * Up to 1 prior line of PARP inhibitor containing treatment CNS Inclusion Criteria: * Untreated CNS metastases (measurable and/or non-measurable) not needing immediate local therapy. * Previously treated CNS metastases Key Exclusion Criteria: * Any investigational or approved anti-cancer therapies administered within 28 days/ before the first dose of EIK1004 (IMP1707) * Have received prior PARP1 selective inhibitors * Mean resting QTcF \> 470 ms or QTcF \< 340 ms * Infections \- An active hepatitis B/C infection * Any known predisposition to bleeding * Unable to swallow oral medications OR have malabsorption syndrome or any other uncontrolled gastrointestinal condition that might impair the bioavailability CNS Exclusion Criteria * Any untreated brain lesions \> 2.0 cm in size. * Ongoing use of systemic corticosteroids for control of symptoms of CNS metastases \< 7 days prior to the first dose of study treatment or requirement for \> 10 mg prednisone/day. * Any brain lesion requiring immediate local therapy, including (but not limited to) a lesion in an anatomic site where an increase in size or possible treatment-related edema may pose risk to the participant (eg, brain stem lesions). * Known, symptomatic leptomeningeal disease. * Have poorly controlled seizures.

Primary outcome measure(s)

Trial sites (10)

FacilityCityRegionStatus
Sarah Cannon Research Institute at HealthOne Denver Colorado Recruiting
Florida Cancer Center Lake Mary Florida Recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts Recruiting
MD Anderson Houston Texas Recruiting
NEXT Oncology San Antonio Texas Recruiting
NEXT Virginia Fairfax Virginia Recruiting
PASO Medical Frankston Victoria Recruiting
Chongqing University Cancer Hospital Chongqing Chongqing Municipality Recruiting
Cancer Hospital of Shandong First Medical University(Shandong Cancer Institute, Shandong Cancer Hospital) Jinan Shandong Recruiting
Fudan University Shanghai Cancer Center Shanghai China Recruiting

More Eikon Therapeutics trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06907043 on ClinicalTrials.gov ↗ ← All trials in China