The Study of Transcranial Magnetic Stimulation in the Regulation of Spinocerebellar Ataxia

NCT06904716 · tracked via the Priya Life Science China tracker

Sponsor

First Affiliated Hospital of Chongqing Medical University

Phase

Not applicable

Started

2023-05-01

Last updated

2025-04-01

Condition(s) studied

Spinocerebellar Ataxia

Investigational drug(s) / intervention(s)

Transcranial magnetic stimulation

Transcranial magnetic stimulation: Repetitive transcranial magnetic stimulation

Study summary

Spinocerebellar ataxia (SCA) is a group of hereditary neurological diseases caused by gene mutations leading to degenerative changes in the cerebellum, brainstem, and spinal cord. A key pathogenic mechanism of SCA is the repeated expansion of cytosine - adenine - guanine (CAG) trinucleotides in the coding region of specific genes. These repeated expansions are translated into abnormally large polyglutamine (PolyQ) tracts in proteins. These polyglutamine (PolyQ) tracts can cause changes in the excitability of the cerebral cortex in SCA patients. Quantitative electroencephalogram analysis (qEEG) is a modern type of electroencephalogram analysis that uses complex mathematical algorithms to process, transform, and analyze EEG signals, bringing new technologies for EEG signal feature extraction: specific frequency band and signal complexity analysis, connectivity analysis, and network analysis. It is sensitive to early neurodegenerative lesions. Using spectral analysis, nonlinear dynamics analysis, and functional connectivity analysis, we can explore the changes in cortical excitability and abnormal brain networks in SCA patients. Currently, the exploration of the quantitative electroencephalogram characteristics of SCA patients is still insufficient.

Eligibility

Sex

ALL

Min age

18 Years

Max age

75 Years

Healthy volunteers

Accepted

Inclusion Criteria: 1. Spinocerebellar ataxia patients confirmed through genetic testing 2. Patient aged 18-75 3. Patients who can walk independently (with the aid of a cane/walker) without assistance from others. 4. The SARA score exceeds 3. Exclusion Criteria: 1. Patients with unstable neurological disorders or accompanying medical conditions (such as stroke, arthritis, etc.) 2. Patients with significantly abnormal clinical indicators identified during screening 3. Patients concurrently participating in another clinical study 4. Patients with untreated intracranial hypertension, depression, dementia, or psychiatric disorders 5. Patients with severe heart disease 6. Patients who are wheelchair users 7. pregnant woman 8. Patients who cannot establish their identity or have limited legal capacity 9. Patients with contraindications for rTMS, including metallic objects in the head, history of neurosurgery, ferromagnetic bioimplants, metal coatings, history of seizures, autism, current use of protease inhibitors or other medications that may increase the risk of rTMS-induced seizures.

Primary outcome measure(s)

Scale for the assessment and rating of ataxia — Baseline and one week post-baseline (after treatment)
The Scale for the Assessment and Rating of Ataxia (SARA) is a clinical tool used to assess the severity of ataxia. The total score range of the SARA scale is 0 to 40 points, with higher scores indicating more severe ataxia symptoms.
Resting - state electroencephalogram — baseline and one week post-baseline (after treatment)
Use electroencephalogram (EEG) to collect the electroencephalogram data of participants with their eyes closed and in a waking state.Using spectral analysis, nonlinear dynamics analysis, and functional connectivity analysis, we can explore the changes in cortical excitability and abnormal brain networks in SCA patients.
Transcranial Magnetic Stimulation - Electroencephalogram（TMS-EEG） — Baseline and one week post-baseline (after treatment)
Transcranial magnetic stimulation is utilized to stimulate the brain, and then EEG data is immediately collected from participants using EEG to collect closed-eye, awake EEG data.Using time-frequency analysis, nonlinear dynamics analysis, and functional connectivity analysis, we can explore the changes in cortical excitability and abnormal brain networks in SCA patients.

Trial sites (1)

Facility	City	Region	Status
the First Affiliatted Hospital of Chongqing medical Uiversity	Chongqing	Chongqing Municipality

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06904716 on ClinicalTrials.gov ↗ ← All trials in China