Identification of Microplastics in Liver, Stomach, Blood, and Feces of Obese Patients and Their Association Analysis with Macrogenomics and Metabolomics.
First Affiliated Hospital of Chongqing Medical University
Phase
Observational
Started
2024-12-01
Last updated
2025-02-14
Condition(s) studied
Obesity and Overweight
Investigational drug(s) / intervention(s)
Measuring the microplastics
Measuring the microplastics: Measuring the type, nature, and abundance of microplastics in stomach, liver, feces, and blood
Study summary
The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the association between obesity and visceral microplastics, and to investigate the effects of microplastics on the visceral microbiota and metabolic profiles of obese patients by combining the macro-genomic and metabolomics approaches.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥18 years old;
* BMI ≧30;
* proposed to undergo bariatric surgery and need to remove part of the liver tissue for fatty liver test;
* complete clinical data and basic information;
* willing to participate in the study and sign the informed consent form.
Exclusion Criteria:
* Receive chemotherapy, radiotherapy, immunotherapy;
* have other history of digestive diseases;
* combined with malignant tumors;
* have serious cardiorespiratory insufficiency and other systemic diseases that affect the choice of treatment plan;
* not willing to participate in this study.
Primary outcome measure(s)
Differences in microbial communities — From the diagnosis of obesity, through study completion, an average of 1 year. Differences in different microbial communities in the stomach, liver, feces, and blood of obese patients
Trial sites (1)
Facility
City
Region
Status
The First Affiliated Hospital of Chongqing Medical University
Chongqing
Chongqing Municipality
More First Affiliated Hospital of Chongqing Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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