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Clinical Trials in China / NCT06821685
Recruiting Phase 1

Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History

NCT06821685 · tracked via the Priya Life Science China tracker
Sponsor
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Phase
Phase 1
Started
2025-02-13
Last updated
2025-11-17

Condition(s) studied

Abortion, HabitualInfertility UnexplainedEmbryo ImplantationPre-Eclampsia

Investigational drug(s) / intervention(s)

autologous decidual-like NK cells

autologous decidual-like NK cells: intrauterine infusion

Study summary

The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.

Eligibility

Sex
FEMALE
Min age
22 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria: * abnormal uterine NK cell function; * have one of the following medical history: unexplained recurrent spontaneous abortions (≥2 spontaneous abortions, including biochemical pregnancy), repeated implantation failure (failure of implantation of good-quality embryos in at least two IVF cycles), unexplained infertility, early-onset severe gestational hypertension or early-onset fetal growth restriction; * have clear fertility desires; * normal ovarian function or with frozen embryos; * edometrium thickness measured by vaginal ultrasound before ovulation or at mid-luteal phase \>= 7mm; * 18kg/m\^2 \< Body mass index \< 30kg/m\^2; Exclusion Criteria: * using progesterone receptor modulator; * chromosomal karyotype abnormalities in one spouse; * severe endometriosis, uterine fibroids affecting the shape of the uterine cavity or the size of the whole uterus more than 2 and a half months of pregnancy, uterine malformation, uterine adhesion or thin endometrium; * uncontrolled autoimmune diseases; * abnormal blood coagulation function, abnormal liver and kidney function, or other uncontrolled basic diseases (hypertension, diabetes, thyroid disease, etc.) that the researcher access which may affect the progress of the study; * history of pelvic malignant tumors; * currently participating in other clinical studies; * allergic to blood products.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
The Affiliated Drum Tower Hospital of Nanjing University Nanjing Jiangsu Recruiting

More The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06821685 on ClinicalTrials.gov ↗ ← All trials in China