The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Phase
Observational
Started
2022-02-01
Last updated
2026-08-18
Condition(s) studied
Toxic EncephalopathyDiquat Poisoning
Investigational drug(s) / intervention(s)
extracorporeal treatment
extracorporeal treatment: Extracorporeal treatments included hemoperfusion (HP) and continuous veno-venous hemodiafiltration (CVVHDF).
Study summary
This ambispective cohort study aims to characterize the relationship between plasma diquat concentrations and organ damage risk.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion criteria:
1. history of oral exposure to diquat solution reported by patient or proxy;
2. a specimen for the diquat plasma concentration collected immediately upon admission;
3. documentation that patients or, in case of unconsciousness of the patient, legal proxies were aware of and agreed to treatment plans.
Exclusion criteria:
1. they had ingested other toxins in addition to diquat (qualitative toxicological screening tests);
2. diquat was not detected in specimens, or plasma concentration data were unavailable;
3. patients with an exposure time (time from exposure to emergency department presentation) longer than 48 hours;
4. data on organ damage were not unavailable;
5. combined with other central nervous system injuries other than toxic encephalopathy.
Primary outcome measure(s)
Survival outcome — 28 days within the index date of presentation at emergency department
Trial sites (1)
Facility
City
Region
Status
Nanjing Drum Tower Hospital
Nanjing
Jiangsu
More The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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