Screening of Small Non-coding RNAs as an Auxiliary Diagnostic Biomarker for Gastric Cancer

Condition(s) studied

Investigational drug(s) / intervention(s)

Analysis of relative quantitative of small non-coding RNAs: Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs

Study summary

Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis. Therefore, there is a strong demand to develop new biomarkers to detect this tumor early. Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as an auxiliary diagnostic biomarker for gastric cancer.

Eligibility

Primary outcome measure(s)

• Analysis of relative quantitative of small non-coding RNAs — an average of 2 years
  Relative quantitative of small non-coding RNAs are detected by quantitative RT-PCR

Trial sites (1)

More Affiliated Hospital of Nantong University trials in China

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