Liposomal Irinotecan and Apatinib in ES-SCLC

Inclusion Criteria: 1. Age range of 18-75 years; 2. Expected survival period ≥ 12 weeks; 3. At least one measurable lesion (according to RECIST V 1.1); 4. For patients who have failed first-line or second-line treatment. Exclusion Criteria: 1. Have received any systemic treatment targeting VEGF or VEGFR in the past, such as treatment with anti angiogenic drugs such as ranibizumab, fipronib, apatinib, anlotinib, lenvatinib, sunitinib, sorafenib. 2. Active or uncontrolled severe infection (CTCAE 5.0 ≥ 2) and/or antibiotic treatment within 2 weeks prior to enrollment; 3. There are multiple factors that affect the absorption of oral medication, such as inability to swallow, nausea and vomiting, chronic diarrhea, and intestinal obstruction; 4. Those deemed unsuitable for inclusion by doctors;