Constant current (CC) subthalamic nucleus deep brain stimulationConstant voltage (CV) subthalamic nucleus deep brain stimulation
Constant current (CC) subthalamic nucleus deep brain stimulation: For subjects who have decided to undergo STN-DBS surgery and meet the inclusion criteria, the constant current (CC) mode is selected as the original electronic modality one week after surgery. Regardless of any changes in programming parameters over the following year, the constant current (CC) mode will be maintained.
Constant voltage (CV) subthalamic nucleus deep brain stimulation: For subjects who have decided to undergo STN-DBS surgery and meet the inclusion criteria, the constant voltage (CV) mode is selected as the original electronic modality one week after surgery. Regardless of any changes in programming parameters over the following year, the constant voltage (CV) mode will be maintained.
Study summary
To compare the efficacy, programming burden, power consumption, and physicians' and patients' satisfaction between current mode and voltage mode of deep brain stimulation in each period one year after surgery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients with idiopathic Parkinson's disease
* Aged 18 to 75, no limited sex
* After bilateral STN-DBS, yet not powered on
Exclusion Criteria:
* Mental disorders or dementia
* Pregnant, lactating women or women who are unable to take effective measures to prevent pregnancy
* Serious health conditions, such as tumors, liver or kidney diseases, etc.
* Epilepsy or other seizure disorders
* Patients with severely deviated electrode placement
* Patients who were unable to voluntarily sign an informed consent form
* Patients who did not agree to cooperate with follow-up
Primary outcome measure(s)
The change rate of MDS-UPDRS III — from baseline to 6 months after surgery MDS-UPDRS III is the motor examination section of the MDS-UPDRS (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale), completed by the evaluator, providing an objective assessment of motor symptoms in patients with Parkinson's disease. MDS-UPDRS III ranges from 0-132. The change rate of MDS-UPDRS III in the Stim-On/Med-On state from baseline to 6 months after surgery will be collected. Positive indicates improvement.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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