Study of HRS-2189 Combined HRS-5041 in Prostate Cancer

Inclusion Criteria: * 18 years to 80 years old (including boundary values), male subjects; * ECOG PS Score: 0\~1; * Histologically or cytologically confirmed prostate adenocarcinoma, and no prior diagnosed as neuroendocrine carcinoma or small cell carcinoma; * Disease progression when enrolled in the study; * Confirmed metastatic disease by CT/MRI/99mTc radioactive bone scan; * Subjects must have a life expectancy ≥ 3 months; * Adequate organ function and marrow function (no corrective treatment within 14 days before first dose); * Male subjects who have partner of childbearing potential should agree to take action of contraception and avoid to donate sperm; * Willing and able to provide written informed consent and comply with the requirements and restrictions in the protocol. Exclusion Criteria: * Known existence of CNS metastasis or meningeal metastasis, or known history of primary CNS tumor; * Severe bone injury caused by bone metastasis identified by investigators, including uncontrolled severe bone pain, pathological bone fracture at the important part and spinal cord compression having occurred for the last 6 months or expected to occur in the near future; * Existence of third space fluid that is not well controlled by effective methods, e.g. drainage; * Has received antitumor surgery, radiotherapy, chemotherapy, targeted therapy, immunological therapy or attenuated live vaccine within 4 weeks before first dose of study therapy (6-week washout period for bicalutamide); * Has been enrolled in other clinical trials within 4 weeks before first dose of study therapy; * Use of other antitumor treatment during the study; * Damage caused by any prior anti-tumor treatment has not recovered to ≤ grade 1 or criteria specified by this study (per NCI-CTCAE 5.0; except alopecia or other tolerable adverse events identified by investigators); * Uncontrolled hypertension, or prior hypertensive crisis or history of hypertension; * Existence of arterial/venous thrombotic event within 6 months before first dose, such as cerebrovascular accidents (including transient ischemic attack, cerebral haemorrhage and cerebral infarction), deep venous thrombosis and pulmonary embolism; * Existence of one of multiple factors that affect oral medication (such as inability to swallow, chronic diarrhea and bowel obstruction), or active gastrointestinal disease or other diseases which may obviously affect distribution of drug absorption, metabolism or excretion; * Has active hepatitis B (HBsAg-positive and HBV DNA≥500 IU/mL), hepatitis C (positive for HCV antibody and HCV RNA above ULN) and hepatic cirrhosis; * Has an active infection requiring antibiotics, antiviral or antifungal treatment, or pyrexia \>38.5℃ of unknown origin during the screening period before first dose of study therapy (patients with pyrexia due to cancer could be enrolled determined by investigator); * Subjects with innate or acquired immunodeficiency (such as HIV infection); Known history of allogeneic organ transplantation or hematopoietic stem cell transplantation; * Other malignancy within prior 3 years before first dose of study therapy, except curatively treated cancer, including radical therapy-treated skin basal cell carcinoma or skin squamous cell carcinoma, papillary thyroid carcinoma, or any type of in situ carcinoma with complete excision, such as in situ cancer of the cervix, ductal carcinoma in situ of breast; * Hypersensitivity to study therapy or any of its excipients; * Uncontrolled cardiovascular clinical symptom or disease within 6 months before first dose of study therapy; * Other conditions that might influence the study and analysis of results in the opinion of the investigator.