Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions

Condition(s) studied

Investigational drug(s) / intervention(s)

surgery: Samples were obtained from patients by surgical excision and matched into groups

Study summary

This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis. Proteomics and transcriptomics are employed to identify molecular differences, while imaging data (MRI/CT) assesses tumor morphology and invasion. In vitro experiments and mechanistic studies validate key findings, exploring how regional molecular differences affect tumor behavior. Data integration combines multi-omics and imaging features to uncover biomarkers and pathways associated with invasiveness and regional specificity, with statistical analysis ensuring significance and reliability.

Eligibility

Primary outcome measure(s)

• Differences in pathological features of tumors — 2025/12/01-2026/12/01
  Cell morphology, proliferation index (e.g. Ki-67), angiogenesis, and other pathological features of tumor tissue in different regions were analyzed to explore region-specific invasive manifestations

Trial sites (1)

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