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Qishenyiqi dripping pills 1 bag, three times a day: Qishenyiqi dripping pills, 1 bag once, three times a day, 12 months
Placebo 1 bag, three times a day: Placebo, 1 bag once, three times a day, 12 months
Study summary
To investigate the efficacy and safety of Qishenyiqi in patients with microvascular angina pectoris. Long-term follow-up of 1 year will be performed to evaluate the effect of Qishenyiqi on coronary flow reserve and adverse cardiovascular events in patients with coronary microvascular disease.
Eligibility
Sex
ALL
Min age
40 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Repeated chest pain attacks with typical exertional angina pectoris or resting angina pectoris attacks;
* Coronary normal or stenosis \< 20%;
* Ischemic depression in ST segment during resting or exercise;
* Blood flow reserve (CFR) of the anterior descending coronary artery \< 2.0;
* Subjects or their guardians agreed to participate in this study.
Exclusion Criteria:
* Previous myocardial infarction or PCI or CABG treatment;
* A history of heart failure;
* Severe arrhythmia;
* Refractory hypertension or hypertension accompanied by left ventricular wall thickness \> 12 mm;
* Familial hypercholesterolemia;
* Takayasu arteritis, Kawasaki disease or coronary artery malformation;
* Pregnant or nursing, or having the intention to give birth within one year;
* Hepatic or renal dysfunction;
* Allergic to contrast agents or traditional Chinese medicines;
* Patients who participated in clinical research of other drugs within 3 months before being selected.
Primary outcome measure(s)
Changes of coronary flow reserve measured by three-dimensional echocardiography from baseline to 12 months after follow-up — 1 year
Trial sites (3)
Facility
City
Region
Status
Qianfoshan Hospital, Shandong University
Jinan
Shandong
Active Not Recruiting
Qilu Hospital of Shandong University
Jinan
Shandong
Recruiting
Jinan Central Hospital Affiliated to Shandong First Medical University
Jinan
Shandong
Recruiting
More Qilu Hospital of Shandong University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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