A Novel Strategy of ECMO Management Using Nafamostat for Regional Combined With Low Intensity Systematic Anticoagulation

NCT06676085 · tracked via the Priya Life Science China tracker

Sponsor

Beijing Chao Yang Hospital

Phase

Not applicable

Started

2025-05-10

Last updated

2026-09-09

Condition(s) studied

ECMO

Investigational drug(s) / intervention(s)

NafamostatHeparin

Nafamostat: Nafamostat combined with unfractionated heparin for anticoagulation

Heparin: unfractionated heparin for anticoagulation

Study summary

ECMO is widely used in patients with refractory respiratory and/or circulatory failure.The data shows that the incidence of bleeding and thrombotic events is still above 40%,and it is closely related to the increase in mortality rate.Therefore, optimizing ECMO anticoagulation management to reduce bleeding and thrombotic events is a key scientific issue that urgently needs to be addressed.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * age older than 18 years old * received VV ECMO because of severe respiratory failure Exclusion Criteria: * anticoagulant contraindications * cerebral infarction or suspected patients * severe hypertension * women in gestational and lactational period * hemophilia * allergic to heparin or Nafamostat * unwilling or unable to complete the study

Primary outcome measure(s)

incidence of ECMO related bleeding or thrombotic events — 28 days
the incidence of ECMO related bleeding or thrombotic events,such as membrane oxygenator or tube thrombotic,local blooding.

Trial sites (1)

Facility	City	Region	Status
Bing Sun	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06676085 on ClinicalTrials.gov ↗ ← All trials in China