Correlation of Blood Serum Renalase and Microcirculation Obstruction in Patients with Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention

NCT06669520 · tracked via the Priya Life Science China tracker

Sponsor

The Third Xiangya Hospital of Central South University

Phase

Observational

Started

2024-08-01

Last updated

2024-11-01

Condition(s) studied

Acute Myocardial Infarction

Study summary

This research will explore the association between blood serum renalase and microcirculation obstruction in patients with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). The investigators aim to identify potential risk factors for microcirculation obstruction in AMI patients after PPCI.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Age ≥ 18 years; 2. STEMI symptom onset time \< 12 hours; 3. STEMI symptom onset time 12-48 hours with persistent ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias; 4. High-risk NSTEMI; 5. Emergency PCI; 6. Voluntary informed consent. Exclusion Criteria: 1. Non-obstructive acute myocardial infarction; 2. Severe chronic kidney disease (defined as estimated glomerular filtration rate \< 20 mL/min per 1.73 m²); 3. Life expectancy \< 1 year; 4. Pregnant or planning to become pregnant; 5. Emergency PCI failure.

Primary outcome measure(s)

Number of Participants with Microvascular Obstruction Assessed by Contrast-Enhanced Magnetic Resonance Imaging 3-7 Days After Percutaneous Coronary Intervention. — 3-7 days after PPCI
Microvascular obstruction (MVO) was qualitatively recognized as a subendocardial lack of enhancement at first-pass perfusion (FPP) sequences and as a hypointense region within the hyperintense infarcted area at early gadolinium enhancement (EGE) and late gadolinium enhancement (LGE) sequences.

Trial sites (1)

Facility	City	Region	Status
The Third Xiangya Hospital of Central South University	Changsha	Hunan	Recruiting

More The Third Xiangya Hospital of Central South University trials in China

The Effect of Nurse-led Health Coaching on Blood Pressure Control and Disease Self-management Among Patients With Hypertension in Huayuan County, Western Hunan, China: a Randomized Controlled Trial Enrolling by invitation

Risk Factors for Microvascular Obstruction Post-Emergency PCI in AMI Patients Recruiting

To Evaluate the Safety and Effectiveness of Intrauterine Adhesion Preventer in the Prevention and Treatment of Intrauterine Adhesions, a Prospective, Multicenter, Randomized Controlled Clinical Trial Recruiting

Clinical Research on a Novel Deep-learning Based System in Mediastinal Endoscopic Ultrasound Scanning Recruiting

Clinical Research on a Novel Deep-learning Based System in Pancreatic Endoscopic Ultrasound Scanning Recruiting

Other trials for the same condition

Prospective Acute Myocardial Infarction Data Bank Starting soon

Abbott Vascular Medical Device Registry Recruiting

Long-Term Follow-Up in Patients With Acute Myocardial Infarction Cohort Recruiting

Acute Myocardial Infarction Clinical Intelligent Decision Support System Active, not recruiting

Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06669520 on ClinicalTrials.gov ↗ ← All trials in China