Single-pulse stimulationPaired-pulse stimulationStepwise frequency stimulationBurst stimulation
Single-pulse stimulation: Investigators use single-pulse electrical stimulations at 1Hz to elicit cortico-cortical evoked potentials
Paired-pulse stimulation: The repetitive delivery of pairs of stimulation pulses is DES patten with a 5-50 ms interval between each pulse, constitutes repetitive paired-pulse stimulation.
Stepwise frequency stimulation: Stepwise incremental stimulation ranging from 5 Hz to 145 Hz following a cyclic pattern.
Burst stimulation: Burst stimulation pattern consisting of short bursts delivered once a second and an intraburst frequency of 50 Hz, 100 Hz, 150 Hz, 175 Hz and 200 Hz
Study summary
The study aims to evaluate modulation effects of burst stimulation patterns via SEEG.
Eligibility
Sex
ALL
Min age
14 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Drug-resistant focal epilepsy
* Justified SEEG exploration in the context of presurgical assessment of epilepsy
* Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis
* Written non-opposition to study participation
Exclusion Criteria:
* Pregnant women (Contraindication to SEEG exploration)
* Psychiatric disorders
* History of psychotic disorders
* History of cranial trauma serious (according to the classification), previous or evolutionary other neurological pathology
* Subjects that experience surgical complications during the implant procedure will be excluded from the study
Primary outcome measure(s)
Modulation Factor — During the trial(up to 3 hours for each subject) Investigators calculate normalized the Modulation Factors of single-pulse electrical stimulation, paired electrical stimulation, stepwise electrical stimulation, and burst electrical stimulation patterns using (stimulation-pre-stimulation)/(stimulation + pre-stimulation)
EEG power in spectral frequency bands — During the trial(up to 3 hours for each subject) Using SEEG-implanted electrodes, the investigators applied electrical stimulation single-pulse electrical stimulation, paired electrical stimulation, stepwise electrical stimulation, and burst electrical stimulation while observing and recording EEG power changes across six spectral frequency bands during the pre-stimulation, stimulation, and post-stimulation periods.
EEG Frequency Bands delta (1-4 Hz) theta (5-8 Hz) alpha (9-12 Hz) beta (13-30 Hz) low gamma (31-70 Hz) high gamma (71-150 Hz)
Phase Locking Value — During the trial(up to 3 hours for each subject) To estimate functional connectivity through the oscillatory synchrony of two brain regions, phase locking value (PLV) provides a measure of inter-regional synchrony based on phase difference between the paired signals.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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