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Clinical Trials in China / NCT06662760
Recruiting Phase 1

Clinical Trial of TQB3002 in Patients With Advanced Cancers

NCT06662760 · tracked via the Priya Life Science China tracker
Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Phase
Phase 1
Started
2024-12-09
Last updated
2025-11-25

Condition(s) studied

Advanced Cancer

Investigational drug(s) / intervention(s)

TQB3002 Tablets

TQB3002 Tablets: TQB3002 is a fourth-generation small molecule Epidermal growth factor receptor (EGFR) inhibitor, which inhibits relevant tyrosine kinase activity and intracellular phosphorylation process by competitively binding to Adenosine triphosphate (ATP) site of intracellular tyrosine kinase binding domain, thereby inhibiting EGFR downstream signaling, ultimately achieving the purpose of inhibiting tumor growth.

Study summary

This is a Phase I study to evaluate the safety, tolerability, and efficacy of TQB3002 in subjects with advanced cancers

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Subjects voluntarily joined this study, signed the informed consent form, and had good compliance; * Age: ≥ 18 years old; Eastern Cooperative Oncology Group (ECOG) score: 0-1 ; Expected survival of more than 3 months; * Histologically or cytologically diagnosed with advanced cancers * Subjects with advanced malignancies who have failed standard therapy or lack effective treatment * Major organs are functioning well; * Female and male subjects of childbearing potential should agree to practice contraception for the duration of the study and for 6 months after the end of the study. Exclusion Criteria: * Current concomitant presence of other malignancies within 5 years prior to the first dose; * Unresolved toxicity above CTCAE Grade 1 due to any prior anti-tumor therapy * Significant surgical treatment, biopsy, or significant traumatic injury within 4 weeks prior to the first dose * Long-term unhealed wounds or fractures * Cerebrovascular accident (including transient ischemic attack, intracerebral hemorrhage, cerebral infarction), deep vein thrombosis, and pulmonary embolism within 6 months prior to the first dose * Swallowing dysfunction, active gastrointestinal diseases or other diseases that significantly affect the absorption, distribution, metabolism and excretion of the study drug, or previous subtotal gastrectomy * A history of psychotropic drug abuse and cannot be abstained from or have a mental disorder * Subjects with any severe and/or uncontrolled disease

Primary outcome measure(s)

Trial sites (11)

FacilityCityRegionStatus
Guangdong Provincial People's Hospital Guangzhou Guangdong Recruiting
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center Shenzhen Guangdong Not Yet Recruiting
Henan Cancer Hospital Zhengzhou Henan Not Yet Recruiting
Jiangsu Province Hospital Nanjing Jiangsu Not Yet Recruiting
The First Affiliated Hospital Of Nanchang University Nanchang Jiangxi Not Yet Recruiting
Shanghai Pulmonary Hospital Shanghai Shanghai Municipality Not Yet Recruiting
The Second Affiliated Hospital of Xi'an Jiaotong University Xi’an Shanxi Not Yet Recruiting
The First Affiliated Hospital of Xi'an Jiao Tong University Xi’an Shanxi Not Yet Recruiting
Sichuan Cancer Hospital Chengdu Sichuan Not Yet Recruiting
Mianyang Central Hospital Mianyang Sichuan Not Yet Recruiting
Yunnan Cancer Hospital Kunming Yunnan Not Yet Recruiting

More Chia Tai Tianqing Pharmaceutical Group Co., Ltd. trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06662760 on ClinicalTrials.gov ↗ ← All trials in China