A Cohort Study on the Efficacy of Bariatric Surgery for Rapidly Progressing Diabetic Nephropathy

NCT06661174 · tracked via the Priya Life Science China tracker

Sponsor

China-Japan Friendship Hospital

Phase

Observational

Started

2023-10-01

Last updated

2024-10-28

Condition(s) studied

Bariatric SurgeriesDiabetic Nephropathy

Investigational drug(s) / intervention(s)

Bariatric surgeryNon-surgical therapy

Bariatric surgery: Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function

Non-surgical therapy: Diet management，exercise，metformin，GLP-1 receptor agonists and other drugs which can lose weight.

Study summary

Establish a cohort of diabetic kidney disease(DKD) patients with intensive weight loss treatment to evaluate the impact of intensive weight loss treatment on the renal prognosis of DKD and construct a prediction model for the improvement of renal outcomes after weight loss.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Age 18 to 65 years old; * BMI\>25Kg/m2 or abdominal obesity (i.e. waist circumference\>90cm for men and\>85cm for women); * eGFR\<30ml/min/1.73m2 or urinary microalbumin≥300mg/g, eGFR\<60ml/min/1.73m2. Exclusion Criteria: * Patients who are taking glucocorticoids; * Combined with tumors; ③Combined with autoimmune diseases; ④Serum albumin\<25g/L.

Primary outcome measure(s)

Total weight loss — 1st, 3rd, 6th and 12th month after intervention, respectively.

Trial sites (1)

Facility	City	Region	Status
China-Japan Friendship Hospital	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06661174 on ClinicalTrials.gov ↗ ← All trials in China