LP352: LP352 will be administered orally or through G-tube/ percutaneous endoscopic gastrostomy (PEG) tube
Placebo: Participants will be administered with matching placebo orally or through G-tube/ PEG tube
This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS. The study consists of 3 main phases: Screening, Titration period, and Maintenance period, followed by a Taper period and Follow-Up. Participants will be randomized to LP352 or placebo. The total duration of the study will be approximately 24 months.
| Facility | City | Region | Status |
|---|---|---|---|
| Arkansas Children's Hospital - Cardiology Clinic | Little Rock | Arkansas | |
| Children's Hospital Los Angeles (CHLA) | Los Angeles | California | |
| University of California Los Angeles (UCLA) - David Geffen School of Medicine - Global Health Pro... | Los Angeles | California | |
| Stanford University - Stanford School of Medicine - Pulmonary and Cystic Fibrosis Center | Palo Alto | California | |
| UCSF Benioff Children's Hospitals - San Francisco | San Francisco | California | |
| Children's Hospital Colorado - Heart Institute | Aurora | Colorado | |
| Children's National Hospital - Children's National Heart Center | Washington D.C. | District of Columbia | |
| NW FL Clinical Research Group, LLC | Gulf Breeze | Florida | |
| Nicklaus Children's Hospital (Miami Children's Hospital) | Miami | Florida | |
| Research Institute of Orlando LLC | Orlando | Florida | |
| Pediatric Epilepsy & Neurology Specialists (PENS) | Tampa | Florida | |
| Rare Disease Research, LLC. (RDR) | Atlanta | Georgia | |
| Northwestern Memorial Hospital | Chicago | Illinois | |
| Northwestern University - Ann & Robert H. Lurie Children's Hospital of Chicago - Center for Cance... | Chicago | Illinois | |
| Mid-Atlantic Epilepsy and Sleep Center - Bethesda | Bethesda | Maryland | |
| Mayo Clinic - Children's Center - Rochester | Rochester | Minnesota | |
| Barnabas Health - Institute of Neurology and Neurosurgery | Livingston | New Jersey | |
| Northeast Regional Epilepsy Group - Morristown | Morristown | New Jersey | |
| NYU Langone Health-NYU Comprehensive Epilepsy Center | New York | New York | |
| Oregon Health & Science University - Blood Brain Barrier and Neuro-Oncology Program | Portland | Oregon | |
| Le Bonheur Children's Hospital - Outpatient Center | Memphis | Tennessee | |
| Child Neurology Consultants of Austin - Austin | Austin | Texas | |
| Cook Children's Jane and John Justin Neurosciences Center | Fort Worth | Texas | |
| The University of Texas Medical School at Houston - UT Gastroenterology | Houston | Texas | |
| MultiCare Health System | Tacoma | Washington | |
| Prince of Wales Hospital (POWH) | Randwick | New South Wales | |
| Sydney Children's Hospital - Randwick | Randwick | New South Wales | |
| The Children's Hospital-Westmead - Heart Centre for Children | Westmead | New South Wales | |
| Royal Brisbane and Women's Hospital (RBWH) | Brisbane | Queensland | |
| Queensland Children's Hospital (Lady Cilento Children's Hospital) | Brisbane | Queensland | |
| Austin Hospital | Heidelberg | Victoria | |
| The Alfred Hospital | Melbourne | Victoria | |
| The Royal Children's Hospital (RCH) Melbourne | Parkville | Victoria | |
| Universitair Ziekenhuis Antwerpen (UZA) | Edegem | Antwerp | |
| Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven | Flemish Brabant | |
| Instituto de Neurologia de Curitiba (INC) | Curitiba | Paraná | |
| Moinhos de Vento Hospital (Hospital Moinhos de Vento) (HMV) | Porto Alegre | Rio Grande do Sul | |
| Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) - Instituto Do Cerebro Do Rio Grand... | Porto Alegre | Rio Grande do Sul | |
| Universidade Estadual de Campinas (UNICAMP) - Hospital das Clinicas (HC) | Campinas | São Paulo | |
| Universidade de Sao Paulo (USP)-Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto ... | Ribeirão Preto | São Paulo |
+ 65 more sites — see the full list on the official registry below.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06660394 on ClinicalTrials.gov ↗ ← All trials in China