Orelabrutinib in Combination with R-CHOP for CD5-positive DLBCL Patients（Rocket Trial）

Key Inclusion Criteria: 1. Subjects fully understand and voluntarily participate in this study and sign informed consent. 2. Aged ≥18 years, both male and female. 3. Pathologically confirmed CD5-positive DLBCL 4. There must be at least one measurable or evaluable lesion that meets the evaluation criteria for Lugano 2014 lymphoma. 5. Eastern Cooperative Oncology Group(ECOG) performance status score of 0-2. 6. Expected survival ≥3 months. 7. Sufficient bone marrow, liver, and kidney function. Key Exclusion Criteria: 1. DLBCL combined with other types of lymphoma. Transformed DLBCL. 2. DLBCL with central nervous system invasion. 3. The patients had previously received BTK inhibitors. 4. The patients have contraindications to any drug in the combined treatment. 5. Patients with the infection of human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome. 6. Inability to swallow tablets, presence of malabsorption syndrome, or any other gastrointestinal disease or dysfunction that may affect the absorption of the study drug. 7. Pregnant and lactating women, and subjects of childbearing age who do not want to use contraception. 8. Mentally ill persons or persons unable to obtain informed consent. 9. The investigators think that the patient is not suitable for the study.