Transverse thoracic muscle plane block (TTMPB) using liposomal bupivacaine and bupivacaine mixtureTransverse thoracic muscle plane block (TTMPB) using bupivacaine hydrochloride
Transverse thoracic muscle plane block (TTMPB) using liposomal bupivacaine and bupivacaine mixture: Liposomal bupivacaine and bupivacaine mixture were used for transverse thoracic muscle plane block (TTMPB) in experimental group.
Transverse thoracic muscle plane block (TTMPB) using bupivacaine hydrochloride: Bupivacaine hydrochloride was used for transverse thoracic muscle plane block (TTMPB) in active control group.
Study summary
In light of the ongoing controversy surrounding the efficacy of bupivacaine liposomes, our study was designed to investigate, for the first time, the differential postoperative analgesic effects between bupivacaine liposomes combined with bupivacaine hydrochloride and bupivacaine hydrochloride alone in transverse thoracic muscle plane block treatment. The aim is to provide evidence-based medical guidance for drug selection in regional block local anesthesia.
Eligibility
Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients aged 18-90 years;
* ASA Class I \~ III;
* Patients undergoing elective median sternotomy.
Exclusion Criteria:
* Emergency surgery;
* Re-operation;
* Coagulation dysfunction;
* Preoperative left ventricular function was poor (ejection fraction \<35%);
* Systemic infection or injection site infection;
* Neuromuscular diseases;
* Mental illness;
* Dependence on psychotropic drugs;
* Allergic to bupivacaine liposomes and bupivacaine;
* Patients have participated in previous trials or have been determined by a surgeon or anesthesiologist to be unsuitable for randomization;
* Failure to obtain written informed consent from the patient or his/her representative
Primary outcome measure(s)
Third-day opioid consumption — 48-72 hours after surgery Opioid consumption was converted to Milligram morphine equivalent (MME) using the analgesic Drug Equivalence calculator.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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