real rTMS on the dlPFC: During real rTM session, participants will perform the regulation of craving (ROC). In the rest phase, participants need to relax and rest. In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Sham (No Treatment): During the sham rTMS session, participants will perform the regulation of craving (ROC). In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Study summary
This study aims to investigate the intervention effects of navigated repetitive transcranial magnetic stimulation (rTMS) on craving regulation in individuals with internet gaming disorder (IGD). The primary objectives include: (1) examining the impact of navigated rTMS over the dorsolateral prefrontal cortex (DLPFC) on the gaming cravings, and craving regulation capacity; and (2) exploring the potential neural mechanisms by which rTMS over the DLPFC improves craving intensity, and craving regulation ability.
Eligibility
Sex
ALL
Min age
18 Years
Max age
30 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* DSM-V gaming disorder \>5 and scored ≥ 50 on a revised version of Young's online Internet addiction test；
* spent more than 50% of their online time gaming；
* engagement in one of four popular Internet game (Arena of Valor,Genshine, LOL, FPS) for over 20 hours per week for at least 1 year.
Exclusion Criteria:
* current or history of use of illegal substances and gambling;
* current or history of psychiatric or neurological illness;
* current use of psychotropic medications;
* cognitive impairment as assessed by the Mini-International Neuropsychiatric Interview；
* surgery, head trauma or heart related diseases in the past year；
* a history of epilepsy or seizures or increased risk of seizures for any reason；
* metal implants or tattoos of the neck or head；
* claustrophobia.
Primary outcome measure(s)
Change in craving scores in the Cue-Reactivity(CR) task — Approximately 10 minutes during real rTMS condition and sham rTMS Comparing the participants who reported craving scores for the game stimuli in the unregulated condition and in the regulated condition in the CR task conducted separately during real rTMS and sham rTMS. Higher scores mean higher craving.
Changes in the DLPFC and craving-related brains (striatum, amygdala) activities in the ROC task following rTMS and sham rTMS — Approximately 14 minutes - 29 minutes after real rTMS and sham rTMS This study will compare the changes in DLPFC activity during the ROC task after real rTMS and sham rTMS. In addition, craving-related brain regions (striatum and amygdala) are also concerned.
Alterations in the functional connectivity between the DLPFC and other brain regions in the ROC task following rTMS and sham rTMS — Approximately 14 minutes - 29 minutes after real rTMS and sham rTMS The present study compares the alterations in functional connectivity between the DLPFC and other brain regions (especially those related to reward) after real TMS and sham TMS.
Trial sites (2)
Facility
City
Region
Status
Medical Ethics Committee of Zhenjiang Mental Health Center
Zhenjiang
Jiangsu
Recruiting
State Key Laboratory of Cognitive Neuroscience and Learning
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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