Platelet Rich Plasma in the Prevention of Adhesion Reformation

Condition(s) studied

Investigational drug(s) / intervention(s)

PRP group: After the completion of hysteroscopic adhesiolysis, recruited participants will be randomized to one of the two treatment groups by computer-generated numbers: Immediately administer uterine perfusion with PRP after surgery, and administered PRP perfusion during hysteroscopy at 4 and 8 weeks after hysteroscopic adhesiolysis, A second-look hysteroscopy and ultrasound assessment of the endometrium will be carried out 4 weeks after the surgery, and again at 8 weeks after the surgery. Control group without PRP treatment.

Study summary

Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium. It seems that the role of postoperative platelet rich plasma（PRP）therapy in the prevention of recurrence of IUA is still controversial. To investigate if PRP therapy can prevent adhesion reformation after adhesiolysis.

After the completion of hysteroscopic adhesiolysis, recruited patients will be randomized to one of the two treatment groups by computer-generated numbers: having PRP after hysteroscopic adhesiolysis; and the control group without PRP treatment. A second-look hysteroscopy and ultrasound assessment of the endometrium will be carried out 4 weeks after the surgery, and again at 8 weeks after the surgery.

Eligibility

Primary outcome measure(s)

• AFS Score at Third-look Hysteroscopy — 8 weeks after operation
  The investigators measured the AFS score between the PRP group and Control group through hysteroscopy 8 weeks after operation. American Fertility Society \[(AFS) score in intrauterine adhesion who underwent hysteroscopic adhesiolysis.The higher the score, the heavier the degree of adhesion. The AFS (American Fertility Society) scoring system for endometrial assessment is as follows: Extent of involvement: 1 point(\<1/3 of the uterine cavity); 2 points(1/3 to 2/3 of the uterine cavity); 4 points(2/3 of the uterine cavity). Type of adhesion:1 point(Filmy); 2 points(Filmy and dense); 4 points(Dense) . Menstrual pattern:1 point(Normal menses); 2 points(Menstrual reduction); 4 points(Amenorrhea) . Points are summed to give a total score ranging from 1 to 12, which is used to classify the degree of endometrial injury or disease:Mild (Grade I): 1 to 4 points;Moderate (Grade II): 5 to 8 points;Severe (Grade III): 9 to 12 points.
• Endometrial thickness under ovulation ultrasound — 3 months
  Ultrasound measurement of endometrial thickness during ovulation period three months after adhesion release surgery

Trial sites (2)

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