Hepatic Safety of Statin Use in Neurology Inpatients

Condition(s) studied

Investigational drug(s) / intervention(s)

stain: This research was conducted in two phases. Initially, a cross-sectional study was performed to assess the correlation between statin usage prior to hospital admission and the initial state of liver enzymes among patients. Subsequently, a retrospective cohort study was undertaken, wherein patients who had not been on statins prior to admission were categorized into two groups based on their statin usage post-admission.

Study summary

This research employs a cross-sectional study and a retrospective cohort study to analyze the liver safety of statin use among inpatients in the neurology department in China from different perspectives. The aim is to supplement evidence-based medicine and provide guidance for the clinical use of statins.

Eligibility

Primary outcome measure(s)

• Aspartate aminotransferase(AST) — 4weeks after admission.
  The specific value of AST, whether the AST was more than 1 times the upper limit of normal (\>1×ULN), and whether it was more than 3×ULN.
• Alanine aminotransferase(ALT) — 4 weeks taken after admission.
  The specific value of ALT, whether the ALT was more than 1 times the upper limit of normal (\>1×ULN), and whether it was more than 3×ULN.

Trial sites (1)

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