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Clinical Trials in China / NCT06566586
Recruiting Phase 2

A Clinical Study to Evaluate the Efficacy and Safety of TQB3702 Tablets Combined With Immunochemotherapy for the Treatment of B-cell Lymphoma

NCT06566586 · tracked via the Priya Life Science China tracker
Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Phase
Phase 2
Started
2024-11-06
Last updated
2024-11-20

Condition(s) studied

B-cell Lymphoma

Investigational drug(s) / intervention(s)

TQB3702 tablets+Chemotherapy regimen →

TQB3702 tablets+Chemotherapy regimen: TQB3702 tablets: Tyrosine kinase inhibitor; Chemotherapy regimen:inhibiting tumor cell proliferation, suppressing DNA synthesis, inducing cell apoptosis, enhancing immune system function, and inhibiting angiogenesis;

Study summary

To evaluate the efficacy and safety of TQB3702 tablets combined with immunochemotherapy for the treatment of B-cell lymphoma

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * The subjects voluntarily joined the study, signed the informed consent, and the compliance was good; * Age: 18 years old ≤ age (when signing the informed consent) ≤75 years old; Eastern cooperative oncology group (ECOG) score: 0-2; Expected survival of more than 3 months; * Histologically confirmed B-cell lymphomas of the following types that meet the 2022 World Health Organization (WHO) diagnostic criteria: 1. Relapsed/refractory indolent B-cell lymphoma 2. Diffuse large B cell lymphoma(DLBCL) * Previous treatment: Relapsed/refractory inert B-cell lymphoma: have received at least one previous line of systemic standard therapy * Have at least one measurable lesion. * The main organs function well. * Female subjects of reproductive age should agree to use contraception (such as Iuds, contraceptives, or condoms) during the study period and for 6 months after the end of the study; Have a negative serum pregnancy test within 7 days prior to study enrollment and must be a non-lactating subject; Male subjects should agree to use avoidance during the study period and for 6 months after the end of the study period. Exclusion Criteria: * Have had or are currently suffering from other malignant tumors within 3 years prior to the first medication. * Known or suspected central nervous system (CNS) aggression. * Relapsed/refractory inert B-cell lymphoma: previous allogeneic hematopoietic stem cell transplantation, or autologous hematopoietic stem cell transplantation within 3 months before the first treatment; * Recurrent/refractory indolent B-cell lymphoma: toxic reactions that do not return to ≤ National Cancer Institute standard for common toxic reactions (NCI-CTC) AE Grade 1 due to any previous treatment, excluding hair loss and fatigue; * Have multiple factors that affect oral drug absorption (such as inability to swallow, chronic diarrhea, and intestinal obstruction); * Received major surgical treatment or significant traumatic injury within 28 days before the start of study treatment; * Hyperkinetic/venous thrombosis events occurred within 6 months before the first medication; * Have a history of psychotropic drug abuse and can not quit or have mental disorders; * Subjects with any severe and/or uncontrolled disease; * Received live vaccine or messenger ribonucleic acid (mRNA) vaccine within 4 weeks before the first dose, or planned to receive live vaccine or mRNA vaccine during the study; * Participated in clinical trials of other antitumor drugs within 4 weeks before the first medication; * Subjects who, in the judgment of the investigator, have concomitant diseases that seriously endanger the safety of the subjects or affect the completion of the study, or subjects who are not suitable for enrollment for other reasons.

Primary outcome measure(s)

Trial sites (30)

FacilityCityRegionStatus
Cancer Hospital Chinise Academy of Medical Sciences Beijing Beijing Municipality Not Yet Recruiting
Gansu Provincial Cancer Hospital Lanzhou Gansu Not Yet Recruiting
Sun Yat-sen University Cancer Center Guangzhou Guangdong Not Yet Recruiting
Guigang City People's Hospital Guigang Guangxi Not Yet Recruiting
Guangxi Medical University Cancer Hospital Nanning Guangxi Not Yet Recruiting
Guangxi Medical University Cancer Hospital Nanning Guangxi Not Yet Recruiting
Harbin Medical University Cancer Hospital Harbin Heilongjiang Not Yet Recruiting
PuYang AnYang District Hospital Anyang Henan Not Yet Recruiting
Puyang People's Hospital Puyang Henan Not Yet Recruiting
Henan Provincial People's Hospital Zhengzhou Henan Not Yet Recruiting
Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University Zhengzhou Henan Not Yet Recruiting
Union Hosiptal, Tongji Medical College, Huazhong University of Science And Technolocy Wuhan Hubei Not Yet Recruiting
Tongji Hospital Tongji Medical College of HUST Wuhan Hubei Not Yet Recruiting
Xiangyang Central Hospital Xiangyang Hubei Not Yet Recruiting
Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha Hunan Not Yet Recruiting
Zhuzhou Central Hospital Zhuzhou Hunan Not Yet Recruiting
The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia Not Yet Recruiting
Jiangsu Provincial People's Hospital Nanjing Jiangsu Not Yet Recruiting
The First Affiliated Hospital of Nanchang University Nanchang Jiangxi Not Yet Recruiting
The second Hospital of dalian Dalian Liaoning Not Yet Recruiting
The Second Affiliated Hospital Of Xi'an Jiaotong University(Xibei Hospital) Xi'an Shaanxi Not Yet Recruiting
Affiliated Cancer Hospital of Shandong First Medical University Jinan Shandong Recruiting
Tai'an Central Hospital Tai’an Shandong Not Yet Recruiting
Tongji Hospital of Tongji University Shanghai Shanghai Municipality Not Yet Recruiting
Shanxi Cancer Hospital Taiyuan Shanxi Not Yet Recruiting
The Affiliated Hospital of Southwest Medical University Luzhou Sichuan Not Yet Recruiting
Zigong First People's Hospital Zigong Sichuan Not Yet Recruiting
Tianjin People's Hospital Tianjin Tianjin Municipality Not Yet Recruiting
Tianjin Medical University Cancer Institute and Hospital Tianjin Tianjin Municipality Not Yet Recruiting
Affiliated Tumor Hospital of Xinjiang Medical University Ürümqi Xinjiang Not Yet Recruiting

More Chia Tai Tianqing Pharmaceutical Group Co., Ltd. trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06566586 on ClinicalTrials.gov ↗ ← All trials in China