blood sampling: Venous blood is collected, and sIgE and BAT will be detected using whole blood and serum, respectively.
Study summary
In this study, basophil activation test (BAT) established by the investigators' lab was evaluated for its sensitivity and specificity in child egg allergy diagnosis. Children with suspected IgE mediated allergy to egg will be recruited in the study. Specific IgE to egg allergen and BAT will be detected. The diagnostic accuracy of the BAT will be assessed against clinical diagnosis based on history, clinical symptoms and laboratory results.
Eligibility
Sex
ALL
Min age
4 Months
Max age
6 Years
Healthy volunteers
No
* 1.Children older than 4 months and younger than 6 years old
* 2.Suspected egg allergy with one or more of the following complaints after intake of egg: Skin or mucous symptoms (e. g. urticaria, increased eczema, or swollen lips) Respiratory symptoms (tight throat or shortness of breath with signs of bronchial obstruction) loss of consciousness Gastrointestinal symptoms (nausea, vomiting, abdominal pain, diarrhea) Ocular symptoms (conjunctival erythema, pruritus, tears) and other related symptoms
* 3\. Sign informed consent by parents/guardians
Exclusion Criteria:
* 1.Patients with hematological tumors, autoimmune diseases, organ transplantation, and immunodeficiency diseases
* 2.Take immunosuppressants, immunomodulators, statins, and inject anesthetics within 3 weeks
Primary outcome measure(s)
Sensitivity of the BAT — 2 days Sensitivity of the BAT compare to clinical comprehensive diagnosis with a threshold value of 5% for the BAT in a population of child egg allergy.
Sensitivity is defined as the capacity for BAT to have a positive result when comprehensive diagnosis result is also positive
Specificity of the BAT — 2 days Specificity is defined as the capacity for BAT to have a negative result when comprehensive diagnosis result is also negative.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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